Evidence map›Paper›PMID 37030190›Full record

ArticleCell calcium2023

iPLA2 inhibition blocks LysoPC-induced TRPC6 externalization and promotes Re-endothelialization of carotid injuries in hypercholesterolemic mice.

Priya Putta, Pinaki Chaudhuri, Rocio Guardia-Wolff, Michael A Rosenbaum, Linda M Graham

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. TRPC6-Mediated CaCells · 2026
    Article
  2. Coronary plaque healing: a safety net or a hazard indicator?Journal of thrombosis and thrombolysis · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Priya PuttaDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, 44195, United States. Electronic address: puttap@ccf.org.
Pinaki ChaudhuriResearch Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, United States.
Rocio Guardia-WolffDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, 44195, United States.
Michael A RosenbaumSurgical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, United States.
Linda M GrahamDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, 44195, United States; Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH, 44195, United States.
Cleveland Clinic · USLouis Stokes Cleveland VA Medical Center · US

Funding

EFFECT OF LIPIDS ON VASCULAR GRAFT HEALINGR01HL064357 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI GRAHAM, LINDA M · 2000 to 2021
$7.0M
Endothelial Healing is Inhibited by Activation of TRPC6 ChannelsI01BX005823 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI ROSENBAUM, MICHAEL AARIC · 2022 to 2025
–
Endothelial Healing is Inhibited by PI3 Kinase-Induced Activation of TRPC6IK2BX003628 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI ROSENBAUM, MICHAEL AARIC · 2017 to 2021
–
BLRD VA I01 BX005823BLRD VA IK2 BX003628NHLBI NIH HHS R01 HL064357
6 · The paper itself

Abstract

Lipid oxidation products, including lysophosphatidylcholine (lysoPC), accumulate at the site of arterial injury after vascular interventions and hinder re-endothelization. LysoPC activates calcium-permeable channels, specifically canonical transient receptor potential 6 (TRPC6) channels that induce a sustained increase in intracellular calcium ion concentration [Ca

Indexed as

CalciumTransient Receptor Potential ChannelsAnimalsFemaleFluorocarbonsKetonesLysophosphatidylcholinesMaleMicePhospholipases A2TRPC6 Cation ChannelTRPC Cation Channels1,1,1,2,2-pentafluoro-7-phenylheptan-3-oneCalciumFluorocarbonsKetonesLysophosphatidylcholinesPhospholipases A2Transient Receptor Potential ChannelsTRPC6 Cation ChannelTrpc6 protein, mouseTRPC Cation ChannelsCalciumCanonical transient receptor potential 6 channelEndothelial migrationHypercholesterolemiaiPLA2 inhibitor FKGK11LysophosphatidylcholinePhospholipase A2

Identifiers

PMID37030190
PMCPMC10234282
OpenAlexW4362719286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.