Evidence map›Paper›PMID 37030157›Full record

ArticleJournal of critical care2023

Echocardiographic profiles and hemodynamic response after vasopressin initiation in septic shock: A cross-sectional study.

Siddharth Dugar, Matthew T Siuba, Gretchen L Sacha, Ryota Sato, Ajit Moghekar, Patrick Collier, Richard A Grimm, Vidula Vachharajani, Seth R Bauer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. [Vasoactive agents in septic shock-individualized strategies].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Siddharth DugarDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Matthew T SiubaDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Gretchen L SachaDepartment of Pharmacy, Cleveland Clinic, USA.
Ryota SatoDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Ajit MoghekarDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Patrick CollierCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, USA.
Richard A GrimmCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, USA.
Vidula VachharajaniDepartment of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, USA.
Seth R BauerCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Pharmacy, Cleveland Clinic, USA. Electronic address: bauers@ccf.org.
Cleveland Clinic · US

Funding

Bioenergetic and Epigenetic Reprogramming by Obesity in SepsisR01GM099807 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VACHHARAJANI, VIDULA · 2012 to 2020
$3.1M
Personalized vasopressor therapy in patients with septic shockK08GM147806 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SETH BAUER · 2022 to 2026
$886k
NIGMS NIH HHS K08 GM147806NIGMS NIH HHS R01 GM099807
6 · The paper itself

Abstract

purposeVasopressin, used as a catecholamine adjunct, is a vasoconstrictor that may be detrimental in some hemodynamic profiles, particularly left ventricular (LV) systolic dysfunction. This study tested the hypothesis that echocardiographic parameters differ between patients with a hemodynamic response after vasopressin initiation and those without a response.

methodsThis retrospective, single-center, cross-sectional study included adults with septic shock receiving catecholamines and vasopressin with an echocardiogram performed after shock onset but before vasopressin initiation. Patients were grouped by hemodynamic response, defined as decreased catecholamine dosage with mean arterial pressure ≥ 65 mmHg six hours after vasopressin initiation, with echocardiographic parameters compared. LV systolic dysfunction was defined as LV ejection fraction (LVEF) <45%.

resultsOf 129 included patients, 72 (56%) were hemodynamic responders. Hemodynamic responders, versus non-responders, had higher LVEF (61% [55%,68%] vs. 55% [40%,65%]; p = 0.02) and less-frequent LV systolic dysfunction (absolute difference  -16%; 95% CI -30%,-2%). Higher LVEF was associated with higher odds of hemodynamic response (for each LVEF 10%, response OR 1.32; 95% CI 1.04-1.68). Patients with LV systolic dysfunction, versus without LV systolic dysfunction, had higher mortality risk (HR(t) = e

conclusionsPre-drug echocardiographic profiles differed in hemodynamic responders after vasopressin initiation versus non-responders.

Indexed as

Shock, SepticVentricular Dysfunction, LeftAdultCatecholaminesCross-Sectional StudiesEchocardiographyHemodynamicsHumansRetrospective StudiesVasoconstrictor AgentsVasopressinsCatecholaminesVasoconstrictor AgentsVasopressinsEchocardiographyNorepinephrineShock, septicVasoconstrictor agentsVasopressin

Identifiers

PMID37030157
PMCPMC10239343
OpenAlexW4362660789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.