Evidence map›Paper›PMID 37029804›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

The relation between hypoxia and proliferation biomarkers with radiosensitivity in locally advanced laryngeal cancer.

Karlijn van den Bovenkamp, Bert van der Vegt, Gyorgy B Halmos, Lorian Slagter-Menkema, Johannes A Langendijk, Boukje A C van Dijk, Ed Schuuring, Bernard F A M van der Laan

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Tumor Hypoxia and CD8Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Karlijn van den BovenkampDepartment of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bert van der VegtDepartment of Pathology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9723 GZ, Groningen, The Netherlands.
Gyorgy B HalmosDepartment of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Lorian Slagter-MenkemaDepartment of Pathology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9723 GZ, Groningen, The Netherlands.
Johannes A LangendijkDepartment of Radiotherapy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Boukje A C van DijkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ed Schuuring *Department of Pathology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9723 GZ, Groningen, The Netherlands. e.schuuring@umcg.nl.ORCID http://orcid.org/0000-0003-3655-143X
Bernard F A M van der Laan *Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTreatment decision-making in advanced-stage laryngeal squamous cell carcinoma (LSCC) is difficult due to the high recurrence rates and the desire to preserve laryngeal functions. New predictive markers for radiosensitivity are needed to facilitate treatment choices. In early stage glottic LSCC treated with primary radiotherapy, expression of hypoxia (HIF-1α and CA-IX) and proliferation (Ki-67) tumour markers showed prognostic value for local control. The objective of this study is to examine the prognostic value of tumour markers for hypoxia and proliferation on locoregional recurrent disease and disease-specific mortality in a well-defined cohort of patients with locally advanced LSCC treated with primary, curatively intended radiotherapy.

methodsIn pre-treatment biopsy tissues from a homogeneous cohort of 61 patients with advanced stage (T3-T4, M0) LSCC primarily treated with radiotherapy, expression of HIF-1α, CA-IX and Ki-67 was evaluated with immunohistochemistry. Demographic data (age and sex) and clinical data (T- and N-status) were retrospectively collected from the medical records. Cox regression analysis was performed to assess the relation between marker expression, demographic and clinical data, and locoregional recurrence and disease-specific mortality.

resultsPatients with high expression of HIF-1α developed significantly more often a locoregional recurrence (39%) compared to patients with a low expression (21%) (p = 0.002). The expression of CA-IX and Ki-67 showed no association with locoregional recurrent disease. HIF-1α, CA-IX and Ki-67 were not significantly related to disease-specific mortality. Clinical N-status was an independent predictor of recurrent disease (p < 0.001) and disease-specific mortality (p = 0.003). Age, sex and T-status were not related to locoregional recurrent disease or disease-specific mortality.

conclusionHIF-1α overexpression and the presence of regional lymph node metastases at diagnosis were independent predictors of locoregional recurrent disease after primary treatment with curatively intended radiotherapy in patients with locally advanced LSCC.

Indexed as

Carbonic AnhydrasesCarcinoma, Squamous CellHead and Neck NeoplasmsLaryngeal NeoplasmsBiomarkers, TumorCell ProliferationHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitKi-67 AntigenNeoplasm Recurrence, LocalPrognosisRadiation ToleranceRetrospective StudiesSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorCarbonic AnhydrasesHypoxia-Inducible Factor 1, alpha SubunitKi-67 AntigenHypoxiaLaryngeal squamous cell carcinomaProliferationRadiosensitivityTumour markers

Identifiers

PMID37029804
PMCPMC10313532
OpenAlexW4362716726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.