Evidence map›Paper›PMID 37029775›Full record

ArticleGlia2023

GPR37L1 controls maturation and organization of cortical astrocytes during development.

TrangKimberly Thu Nguyen, Chad R Camp, Juleva K Doan, Stephen F Traynelis, Steven A Sloan, Randy A Hall

Open access · bronzeAbstract read
In one paragraph

Article in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

TrangKimberly Thu NguyenDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Chad R CampDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Juleva K DoanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Stephen F TraynelisDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Steven A SloanDepartment of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
Randy A HallDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-8318-8728
Emory University · US

Funding

Glutamate receptors and human neurological diseaseR35NS111619 · NINDS · EMORY UNIVERSITY · PI Stephen F Traynelis · 2019 to 2026
$6.6M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
Control of Seizure and Migraine Susceptibility by GPR37L1R01NS123447 · NINDS · EMORY UNIVERSITY · PI HALL, RANDY A. · 2021 to 2025
$2.4M
Loss of Grin2a Promotes Hippocampal Hyperexcitability and Epileptiform ActivityF31NS113530 · NINDS · EMORY UNIVERSITY · PI CAMP, CHAD R. · 2020 to 2022
$135k
NIGMS NIH HHS T32 GM008602NIGMS NIH HHS T32-GM008602NINDS NIH HHS F31 NS113530NINDS NIH HHS F31-NS113530NINDS NIH HHS R01 NS123447NINDS NIH HHS R01-NS123447NINDS NIH HHS R35 NS111619NINDS NIH HHS R35-NS111619
6 · The paper itself

Abstract

Astrocyte maturation is crucial to proper brain development and function. This maturation process includes the ramification of astrocytic morphology and the establishment of astrocytic domains. While this process has been well-studied, the mechanisms by which astrocyte maturation is initiated are not well understood. GPR37L1 is an astrocyte-specific G protein-coupled receptor (GPCR) that is predominantly expressed in mature astrocytes and has been linked to the modulation of seizure susceptibility in both humans and mice. To investigate the role of GPR37L1 in astrocyte biology, RNA-seq analyses were performed on astrocytes immunopanned from P7 Gpr37L1

Indexed as

AstrocytesReceptors, G-Protein-CoupledAnimalsHumansMiceSeizuresGPR37L1 protein, humanReceptors, G-Protein-Coupleddiseaseepilepsyexpressiongliamorphologyprocessestiling

Identifiers

PMID37029775
PMCPMC10315172
OpenAlexW4362717115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.