ArticlePlant communications2023
Genome-wide scan for oil quality reveals a coregulation mechanism of tocopherols and fatty acids in soybean seeds.
Article in Plant communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- Coordinating structure-guided design and cis-regulatory optimization to engineer elite herbicide-tolerance alleles in crops.Nature plants · 2026Article
- Genome-Wide Association Study Reveals Novel Loci and Candidate Genes of Vitamin E Content in Sesame (Antioxidants (Basel, Switzerland) · 2026Article
- A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing.Journal of integrative plant biology · 2026Review
- Genome-wide association study and transcriptomic analysis reveal new genes for unsaturated fatty acid contents in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A balance between glycitein and glyceollins governed by isoflavone 6-hydroxylase confers soybean resistance toProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- An alternative splicing caused by a natural variation in BnaC02.VTE4 gene affects vitamin E and glucosinolate content in rapeseed (Brassica napus L.).Plant biotechnology journal · 2025Article
- Vitamin E in Plants: Biosynthesis Pathways, Biofortification Strategies, and Regulatory Dynamics.International journal of molecular sciences · 2025Review
- Dynamic identification of candidate genes associated with higher tocopherol biosynthesis inFrontiers in plant science · 2025Article
- Identification of superior haplotypes and candidate gene for seed size-related traits in soybean (Molecular breeding : new strategies in plant improvement · 2025Article
- Heterologous Expression of SunflowerPlants (Basel, Switzerland) · 2024Article
- The reference genome of seed hemp (Cannabis sativa) provides new insights into fatty acid and vitamin E synthesis.Plant communications · 2024Article
- Isoflavonoid metabolism in leguminous plants: an update and perspectives.Frontiers in plant science · 2024Review
- Genome-wide association study and genotypic variation for the major tocopherol content in rice grain.Frontiers in plant science · 2024Article
- Proteomic and Low-Polar Metabolite Profiling Reveal Unique Dynamics in Fatty Acid Metabolism during Flower and Berry Development of Table Grapes.International journal of molecular sciences · 2023Article
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9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Tocopherols (vitamin E) play essential roles in human health because of their antioxidant activity, and plant-derived oils are the richest sources of tocopherols in the human diet. Although soybean (Glycine max) is one of the main sources of plant-derived oil and tocopherol in the world, the relationship between tocopherol and oil in soybean seeds remains unclear. Here, we focus on dissecting tocopherol metabolism with the long-term goal of increasing α-tocopherol content and soybean oil quality. We first collected tocopherol and fatty acid profiles in a soybean population (>800 soybean accessions) and found that tocopherol content increased during soybean domestication. A strong positive correlation between tocopherol and oil content was also detected. Five tocopherol pathway-related loci were identified using a metabolite genome-wide association study strategy. Genetic variations in three tocopherol pathway genes were responsible for total tocopherol content and composition in the soybean population through effects on enzyme activity, mainly caused by non-conserved amino acid substitution or changes in gene transcription level. Moreover, the fatty acid regulatory transcription factor GmZF351 directly activated tocopherol pathway gene expression, increasing both fatty acid and tocopherol contents in soybean seeds. Our study reveals the functional differentiation of tocopherol pathway genes in soybean populations and provides a framework for development of new soybean varieties with high α-tocopherol content and oil quality in seeds.
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