ArticleJournal of animal science and biotechnology2023
Effects of high-grain diet feeding on fatty acid profiles in milk, blood, muscle, and adipose tissue, and transcriptional expression of lipid-related genes in muscle and adipose tissue of dairy cows.
Article in Journal of animal science and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 8 citations in OpenAlex.
- Integrated Transcriptomic and Metabolomic Profiling Reveals Candidate Genes and Metabolites Associated with Abdominal Fat Deposition in Pekin Ducks.Animals : an open access journal from MDPI · 2026Article
- Effects of 5,6-dimethylbenzimidazole and cobalt supplementation in high-concentrate diets on rumen fermentation and microorganisms and ruminal metabolome in sheep.BMC veterinary research · 2025Article
- Comprehensive Characterization of Serum Lipids of Dairy Cows: Effects of Negative Energy Balance on Lipid Remodelling.Metabolites · 2025Article
- Dietary supplementation with corn distillers' dried grains with solubles improves egg quality in Haidong chickens by promoting beneficial gut microbiota and modulating serum biochemical profiles.Frontiers in microbiology · 2025Article
- Effects of High-Grain Diet on Performance, Ruminal Fermentation, and Rumen Microbial Flora of Lactating Holstein Dairy Cows.Animals : an open access journal from MDPI · 2024Article
- Changes in blood biochemical parameters in highly productive cows with ketosis.Veterinary world · 2024Article
- Association of Metabolic Disease Occurrence on Milk Fatty Acid Composition and Rumination Time in Early Lactation Dairy Cows and Evaluation of Their Potential as Diagnostic Indicators.Animal science journal = Nihon chikusan GakkaihoArticle
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4 authors at 1 institution in 1 country.
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Abstract
backgroundHigh-grain (HG) diets affect lipid metabolism in the liver and mammary tissue of dairy cows, but its effects on muscle and adipose tissue have not been wide evaluated. Thus, the aim of this study is to clarify this issue.
methodsTwelve Holstein cows were randomly divided into two groups: conventional diet group (CON, n = 6) and the HG diet group (n = 6). On day 7 of week 4, rumen fluid was sampled to measure pH, milk was sampled to measure components, and blood was sampled to measure biochemical parameters and fatty acid composition. After the experiment, cows were slaughtered to collect muscle and adipose tissue for fatty acid composition and transcriptome analysis.
resultsHG feeding decreased the ruminal pH, milk's fat content and long-chain fatty acid proportion (P < 0.05) and increased the proportion of short- and medium-chain fatty acids in the milk (P < 0.05) as compared with CON diets. The concentrations of blood cholesterol, low-density lipoprotein, and polyunsaturated fatty acids in the HG cows were lower than those in CON cows (P < 0.05). In muscle tissue, HG feeding tended to increase the triacylglycerol (TG) concentration (P < 0.10). Transcriptome analysis revealed changes in the biosynthesis of the unsaturated fatty acids pathway, the regulation of lipolysis in the adipocytes pathway, and the PPAR signalling pathway. In adipose tissue, HG feeding increased the concentration of TG and decreased the concentration of C18:1 cis9 (P < 0.05). At the transcriptome level, the fatty acid biosynthesis pathway, linoleic acid metabolism pathway, and PPAR signalling pathway were activated.
conclusionHG feeding leads to subacute rumen acidosis and a decreased milk fat content. The fatty acid profiles in the milk and plasma of dairy cows were changed by HG feeding. In muscle and adipose tissue, HG feeding increased TG concentration and up-regulated the expression of genes related to adipogenesis, while down-regulated the expression of genes related to lipid transport. These results complement our knowledge of the fatty acid composition of muscle and adipose tissue in dairy cows and expand our understanding of the mechanisms by which HG diets affect lipid metabolism in muscle and adipose tissue.
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