Evidence map›Paper›PMID 37029394›Full record

ArticleClinical and molecular allergy : CMA2023

Diagnostic accuracy of atopy patch test in children with cow's milk allergy.

Prapasri Kulalert, Padcha Pongcharoen, Paskorn Sritipsukho, Sukkrawan Intraakhao, Punnapat Piriyanon, Patcharapa Thaweekul, Sira Nanthapisal, Orapan Poachanukoon

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and molecular allergy : CMA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Prapasri KulalertDepartment of Clinical Epidemiology, Faculty of Medicine, Thammasat University, Pathum Thani, 12120, Thailand. prapasrikulalert@gmail.com.
Padcha PongcharoenDepartment of Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Paskorn SritipsukhoDepartment of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Sukkrawan IntraakhaoDepartment of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Punnapat PiriyanonDepartment of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Patcharapa ThaweekulDepartment of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Sira NanthapisalDepartment of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Orapan PoachanukoonDepartment of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Thammasat University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe accuracy of an atopy patch test (APT) for fresh cow's milk allergy is controversial. Few studies have focused on commercial extract solutions. We aimed to evaluate the diagnostic performance of the APT in cow's milk allergic children using fresh cow's milk and commercial extracts of cow's milk and its components including casein, α-lactalbumin, and β-lactoglobulin.

methodsA prospective study was carried out in children with a history of cow's milk allergy. Children underwent the skin prick test (SPT) and APT with fresh cow's milk, powdered cow's milk, and commercial extracts of cow's milk, casein, α-lactalbumin, and β-lactoglobulin. Oral food challenge (OFC) was confirmed in all children.

resultsA total of 37 patients participated (mean age 13.14 ± 7.26 months). Only 5 (13.51%) patients had positive OFC to cow's milk. The sensitivity of the APT using fresh cow's milk was 40%, specificity was 65.6%, PPV was 15.4%, and NPV was 87.5%. The sensitivity of the APT using powdered cow's milk was 40%, 60.7% for specificity, 15.4% for PPV, and 58% for NPV. The sensitivity and PPV of the APT using commercial solutions of cow's milk, casein, α-lactalbumin, and β-lactoglobulin were zero. The specificities were 90.6%, 93.8%, 100%, and 100% for α-lactalbumin, cow's milk, casein, and β-lactoglobulin, respectively.

conclusionsAPT using commercial solutions showed higher specificity than fresh milk. The specificity increased using a protein component allergen.

Indexed as

Atopy patch testChildCow’s milk allergyDiagnostic accuracy

Identifiers

PMID37029394
PMCPMC10080736
OpenAlexW4362700936

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.