Evidence map›Paper›PMID 37029389›Full record

ReviewVirology journal2023

Revolutionizing viral disease vaccination: the promising clinical advancements of non-replicating mRNA vaccines.

Xiao Guo, Dongying Liu, Yukai Huang, Youcai Deng, Ying Wang, Jingrui Mao, Yuancheng Zhou, Yongai Xiong, Xinghong Gao

Open access · goldAbstract readReview
In one paragraph

Review in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xiao Guo *School of Basic Medicine, Zunyi Medical University, West No. 6 Xuefu Road, Xinpu District, Zunyi, 563006, Guizhou, People's Republic of China.
Dongying Liu *School of Basic Medicine, Zunyi Medical University, West No. 6 Xuefu Road, Xinpu District, Zunyi, 563006, Guizhou, People's Republic of China.
Yukai Huang *School of Basic Medicine, Zunyi Medical University, West No. 6 Xuefu Road, Xinpu District, Zunyi, 563006, Guizhou, People's Republic of China.
Youcai DengDepartment of Hematology, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.
Ying WangModern Medical Teaching and Research Section, Department of Tibetan Medicine, University of Tibetan Medicine, No. 10 Dangre Middle Rd, Chengguan District, Lhasa, 850000, Tibet Autonomous Region, People's Republic of China.
Jingrui MaoSchool of Basic Medicine, Zunyi Medical University, West No. 6 Xuefu Road, Xinpu District, Zunyi, 563006, Guizhou, People's Republic of China.
Yuancheng ZhouLivestock and Poultry Biological Products Key Laboratory of Sichuan Province, Sichuan Animal Science Academy. No, 6 Niusha Road, Jinjiang District, Chengdu, 610299, People's Republic of China.
Yongai XiongSchool of Pharmacy, Zunyi Medical University, West No. 6 Xuefu Road, Xinpu District, Zunyi, 563006, Guizhou, People's Republic of China. xya180@sina.com.
Xinghong GaoSchool of Basic Medicine, Zunyi Medical University, West No. 6 Xuefu Road, Xinpu District, Zunyi, 563006, Guizhou, People's Republic of China. myggxh@126.com.
Zunyi Medical University · CNArmy Medical University · CNSichuan Animal Science Academy · CNTibet Autonomous Region People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mRNA vaccine technology was developed rapidly during the global pandemic of COVID-19. The crucial role of the COVID-19 mRNA vaccine in preventing viral infection also have been beneficial to the exploration and application of other viral mRNA vaccines, especially for non-replication structure mRNA vaccines of viral disease with outstanding research results. Therefore, this review pays attention to the existing mRNA vaccines, which are of great value for candidates for clinical applications in viral diseases. We provide an overview of the optimization of the mRNA vaccine development process as well as the good immune efficacy and safety shown in clinical studies. In addition, we also provide a brief description of the important role of mRNA immunomodulators in the treatment of viral diseases. After that, it will provide a good reference or strategy for research on mRNA vaccines used in clinical medicine with more stable structures, higher translation efficiency, better immune efficacy and safety, shorter production time, and lower production costs than conditional vaccines to be used as preventive or therapeutic strategy for the control of viral diseases in the future.

Indexed as

COVID-19Viral VaccinesVirus DiseasesCOVID-19 VaccinesHumansmRNA VaccinesRNA, MessengerVaccinationVaccines, SyntheticCOVID-19 VaccinesmRNA VaccinesRNA, MessengerVaccines, SyntheticViral VaccinesClinical research advancesNon-replicating mRNA vaccinesVaccine structureViral disease

Identifiers

PMID37029389
PMCPMC10081822
OpenAlexW4362703408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.