Evidence map›Paper›PMID 37029365›Full record

ArticleBMC infectious diseases2023

Norepinephrine combined with phenylephrine versus norepinephrine in patients with septic shock: a retrospective cohort study.

Dan He, Hai Hu, Liang Hong, Luming Zhang, Xuehao Lu, Wan-Jie Gu, Jun Lyu, Haiyan Yin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Dan He *Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Hai Hu *Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Liang Hong *Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Luming ZhangDepartment of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Xuehao LuDepartment of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Wan-Jie GuDepartment of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jun LyuDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China. lyujun2020@jnu.edu.cn.
Haiyan YinDepartment of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China. Yinhaiyan1867@126.com.
First Affiliated Hospital of Jinan University · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CNHengyang Academy of Agricultural Sciences · CNNanjing Medical University · CN

Funding

Appropriate Technology of Hunan Health Commission, China 202218015798Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University, China JNU1AF-CFTP-2022-a01235National Natural Science Foundation of China (82072232, 81871585)Science and Technology Projects in Guangzhou, China 202201020054
6 · The paper itself

Abstract

backgroundPhenylephrine (PE) and norepinephrine (NE) may be used to maintain adequate blood pressure and tissue perfusion in patients with septic shock, but the effect of NE combined with PE (NE-PE) on mortality remains unclear. We hypothesized that NE-PE would not inferior to NE alone for all-cause hospital mortality in patients with septic shock.

methodsThis single-center, retrospective cohort study included adult patients with septic shock. According to the infusion type, patients were divided into the NE-PE or NE group. Multivariate logistic regression, propensity score matching and doubly robust estimation were used to analyze the differences between groups. The primary outcome was the all-cause hospital mortality rate after NE-PE or NE infusion.

resultsAmong 1, 747 included patients, 1, 055 received NE and 692 received NE-PE. For the primary outcome, the hospital mortality rate was higher in patients who received NE-PE than in those who received NE (49.7% vs. 34.5%, p < 0.001), and NE-PE was independently associated with higher hospital mortality (odds ratio = 1.76, 95% confidence interval = 1.36-2.28, p < 0.001). Regarding secondary outcomes, patients in the NE-PE group had longer lengths of stay in ICU and hospitals. Patients in the NE-PE group also received mechanical ventilation for longer durations.

conclusionsNE combined with PE was inferior to NE alone in patients with septic shock, and it was associated with a higher hospital mortality rate.

Indexed as

NorepinephrineShock, SepticAdultBlood PressureHumansPhenylephrineRetrospective StudiesNorepinephrinePhenylephrineMIMIC-IIINorepinephrinePhenylephrinePropensity score matchingSepsisSeptic shock

Identifiers

PMID37029365
PMCPMC10082526
OpenAlexW4362696883

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.