Evidence map›Paper›PMID 37029315›Full record

ArticleNeurocritical care2023

Measuring Consciousness in the Intensive Care Unit.

Brian L Edlow, Matteo Fecchio, Yelena G Bodien, Angela Comanducci, Mario Rosanova, Silvia Casarotto, Michael J Young, Jian Li, Darin D Dougherty, Christof Koch and 3 more

Abstract read
In one paragraph

Article in Neurocritical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Covert brain complexity in the intensive care unit.Cortex; a journal devoted to the study of the nervous system and behavior · 2026
    Article
  2. Article
  3. Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Review
  4. Article
  5. Covert neural and autonomic signatures of shared perception.Social cognitive and affective neuroscience · 2026
    Article
  6. Review
  7. Covert consciousness: what's in a name?Brain : a journal of neurology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Functional near-infrared spectroscopy: A novel tool for detecting consciousness after acute severe brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Observational
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brian L EdlowCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. bedlow@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-7235-8456
Matteo FecchioCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yelena G BodienCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Angela ComanducciIRCCS Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
Mario RosanovaDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Silvia CasarottoIRCCS Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
Michael J YoungCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jian LiCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Darin D DoughertyAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Christof KochMindScope Program, Allen Institute, Seattle, WA, USA.
Giulio TononiDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Marcello MassiminiIRCCS Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
Melanie BolyDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA.

Funding

A Connectome-Based Clinical Trial Platform to Promote Early Recovery of Consciousness after Traumatic ComaDP2HD101400 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, BRIAN L. · 2019 to 2019
$2.5M
electroencephalography and single-unit recordingsK23NS112473 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI BOLY, MELANIE · 2021 to 2025
$815k
Brainstem Connectome Mapping to Guide Targeted Stimulant Therapy in Patients with Traumatic ComaR21NS109627 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, BRIAN L. · 2019 to 2020
$480k
An Ethical Approach to Detecting Covert ConsciousnessF32MH123001 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI YOUNG, MICHAEL J · 2020 to 2022
$159k
NICHD NIH HHS DP2 HD101400NIMH NIH HHS F32 MH123001NINDS NIH HHS K23 NS112473NINDS NIH HHS R21 NS109627
6 · The paper itself

Abstract

Early reemergence of consciousness predicts long-term functional recovery for patients with severe brain injury. However, tools to reliably detect consciousness in the intensive care unit are lacking. Transcranial magnetic stimulation electroencephalography has the potential to detect consciousness in the intensive care unit, predict recovery, and prevent premature withdrawal of life-sustaining therapy.

Indexed as

ConsciousnessTranscranial Magnetic StimulationConsciousness DisordersElectroencephalographyHumansIntensive Care UnitsComaComplexityConsciousnessTranscranial magnetic stimulation electroencephalography (TMS-EEG)

Identifiers

PMID37029315
PMCPMC11421303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.