ArticlePharmaceutical research2023
Polymorphism of Pradofloxacin: Crystal Structure Analysis, Stability Study, and Phase Transformation Behavior.
Article in Pharmaceutical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Insight into the Manipulation Mechanism of Polymorphic Transformation by Polymers: A Case of Cimetidine.Pharmaceutical research · 2024Article
- Novel Pharmaceutical Cocrystals of Tegafur: Synthesis, Performance, and Theoretical Studies.Pharmaceutical research · 2024Article
- Article
- Preparation and Evaluation of Inhalable Amifostine Microparticles Using Wet Ball Milling.Pharmaceutics · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposePradofloxacin is an important antibiotic with poor physical stability. At present, there is no systematic study on its polymorphic form. The purpose of this study is to develop new crystal forms to improve the stability of Pradofloxacin and systematically study the crystal transformation relationships to guide industrial production.
methodIn this work, three solvent-free forms (Form A, Form B and Form C), a new dimethyl sulfoxide solvate (Form PL-DMSO) and a new hydrate (Form PL-H) were successfully obtained and the single crystal data of Form A, Form B and Form PL-DMSO were solved for the first time. Various solid state analysis techniques and slurry experiments have been used to evaluate the stability and determine phase transformation relationships of five crystal forms, the analysis of crystal structure provided theoretical support for the results.
resultThe water vapor adsorption and desorption experiences of Forms A, B, C and Form PL-H were studied, and the results show that the new hydrate has good hygroscopic stability and certain development potential. The thermal stability of different forms was determined by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) and the crystal structure shows that there are more hydrogen bonds and C - H···π interactions in form B, which is the reason why Form B is more stable than form A. Finally, the phase transformation relationships of the five crystal forms were systematically studied and discussed.
conclusionThese results are helpful to provide guiding methods in the production and storage of pradofloxacin.
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Registered trials
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