ArticleScientific reports2023
Sex differences in hepatic ischemia‒reperfusion injury: a cross-sectional study.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Transient liver enzyme elevations following laparoscopic cholecystectomy: a comprehensive review.Updates in surgery · 2025Review
- Contribution of sympathetic nervous system activation to endothelial ischemia reperfusion injury in healthy adults.Physiological reports · 2025Article
- Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats.World journal of gastroenterology · 2025Article
- Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice.World journal of gastroenterology · 2025Article
- Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis.Critical care (London, England) · 2024Article
- Sex-Specific Effects of Estradiol and Progesterone in Ischemic Kidney Injury.International journal of molecular sciences · 2024Article
- The combinatorial effect of age and biological sex on alloimmunity and transplantation outcome.Frontiers in transplantation · 2023Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have shown that males suffer more severe damage than females in the process of ischemia and reperfusion of the brain, heart and kidney. Accordingly, our study will reveal the correlation between the severity of hepatic ischemia‒reperfusion injury (HIRI) and sex, and preliminarily analyze the underlying mechanism. A total of 75 patients who were considered to have "benign liver tumors" at the initial admission and underwent partial hepatectomy were enrolled. We identified potential differences between different groups and discussed the correlation between the severity of HIRI and sex through a comparative analysis. Results showed that HIRI was more severe in males than in females, especially in younger patients. To explore whether estrogen level differences are the main reason for the sex differences in HIRI, we further revealed that HIRI in premenopausal females was more severe than that in postmenopausal females. By comparing the levels of gonadal hormones, we speculated that multiple gonadal hormones, including follicle-stimulating hormone, luteinizing hormone and testosterone, may jointly participate in the regulation of sex differences in HIRI together with estrogen.
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