Evidence map›Paper›PMID 37029150›Full record

ArticleNPJ breast cancer2023

High-dimensional immune cell profiling of cerebrospinal fluid from patients with metastatic breast cancer and leptomeningeal disease.

K W Im, L A Huppert, L Malevanchik, H S Rugo, A J Combes, M J Campbell, M F Krummel, M E Melisko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

K W Im *Department of Pathology and ImmunoX Initiative, University of California at San Francisco, San Francisco, CA, 94143, USA. kwok.im@ucsf.edu.ORCID http://orcid.org/0000-0002-8939-1532
L A Huppert *Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Laura.Huppert@ucsf.edu.
L MalevanchikDivision of Hospital Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6004-4238
H S RugoDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6710-4814
A J CombesDepartment of Pathology and ImmunoX Initiative, University of California at San Francisco, San Francisco, CA, 94143, USA.
M J CampbellDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3788-9240
M F KrummelDepartment of Pathology and ImmunoX Initiative, University of California at San Francisco, San Francisco, CA, 94143, USA.
M E MeliskoDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USSan Francisco General Hospital · US

Funding

Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
NCI NIH HHS T32 CA108462
6 · The paper itself

Abstract

Leptomeningeal disease (LMD) is a devastating complication of metastatic breast cancer (MBC). In this non-therapeutic study, we enrolled 12 patients with MBC and known or suspected LMD who were undergoing a lumbar puncture as part of clinical care and collected extra cerebrospinal fluid (CSF) and a paired blood sample from each patient at a single time point. Of the 12 patients, 7 patients are confirmed to have LMD based on positive cytology and/or convincing MRI imaging (LMD

Identifiers

PMID37029150
PMCPMC10082042
OpenAlexW4362699802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.