ArticleNature communications2023
Associations between mental health, blood pressure and the development of hypertension.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Life satisfaction and blood pressure: A coordinated analysis of 16 cohorts.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Pooled it
- The Association Between Sleep Duration and the Risk of Hypertension: A Systematic Review and Meta-analysis of Cohort Studies.Journal of general internal medicine · 2025Pooled it
- Association between Early-Onset Metabolic Diseases and Adverse Mental Health Conditions: A Nationwide Cross-Sectional Study.Yonsei medical journal · 2026Article
- The effect of internal migration on blood pressure among a cohort of young adults in South Africa.Social science & medicine (1982) · 2026Article
- Article
- Emotional Vitality, Flourishing, and Healthy Lifestyles in Young Adults: A Longitudinal Study.International journal of behavioral medicine · 2026Article
- Causal relationship between tinnitus and 8 psychiatric phenotypes: a Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Volatile organic compound exposure and depression risk: insights from individual, mixture, and sex-stratified analyses.BMC public health · 2026Article
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Multidimensional sleep health and resting blood pressure in young adults: the role of negative affect.Journal of behavioral medicine · 2026Article
- Associations between symptoms of depression and anxiety with left ventricular hypertrophy among Hispanic/Latino participants of the Hispanic Community Health Study/Study of Latinos.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Association between systolic blood pressure trajectories and successful aging in middle-aged and elderly Chinese individuals: a longitudinal study.BMC public health · 2025Article
- Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study.Molecular psychiatry · 2025Article
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
- Fundamental role of brain-organ interaction in behavior-driven holistic homeostasis.Fundamental research · 2025Review
- Discovery of Personalized Treatment for Immuno-Metabolic Depression-Focus on 11beta Hydroxysteroid Dehydrogenase Type 2 (11betaHSD2) and Toll-like Receptor 4 (TLR4) Inhibition with Enoxolone.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Metabolic Modulators in Depression: Emerging Molecular Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple studies have reported a link between mental health and high blood pressure with mixed or even contradictory findings. Here, we resolve those contradictions and further dissect the cross-sectional and longitudinal relationship between mental health, systolic blood pressure, and hypertension using extensive psychological, medical and neuroimaging data from the UK Biobank. We show that higher systolic blood pressure is associated with fewer depressive symptoms, greater well-being, and lower emotion-related brain activity. Interestingly, impending hypertension is associated with poorer mental health years before HTN is diagnosed. In addition, a stronger baseline association between systolic blood pressure and better mental health was observed in individuals who develop hypertension until follow-up. Overall, our findings offer insights on the complex relationship between mental health, blood pressure, and hypertension, suggesting that-via baroreceptor mechanisms and reinforcement learning-the association of higher blood pressure with better mental health may ultimately contribute to the development of hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.