ArticleOpen heart2023
Temporal trends in the incidence of infective endocarditis in patients with a prosthetic heart valve.
Article in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Approaching the post-antibiotic era: phage therapy current practices and future horizons.mBio · 2026Review
- Valve-Related Outcomes up to Six Years of a Next-Generation Bovine Pericardial Bioprosthesis Compared with Its Predecessor: A Propensity-Matched Analysis.Medical sciences (Basel, Switzerland) · 2026Article
- Sex Differences in Clinical Outcomes and Loss of Life Expectancy After Aortic Valve Surgery for Infective Endocarditis: A SWEDEHEART Study.Journal of the American Heart Association · 2026Observational
- Infective Endocarditis: A Contemporary Review of Epidemiology, Diagnosis, and Management.Antibiotics (Basel, Switzerland) · 2026Review
- Emerging insights into infective endocarditis in the era of transcatheter aortic valve implantation.Frontiers in cellular and infection microbiology · 2026Review
- Clinical and Prognostic Differences Between Mechanical Versus Biological Prosthetic Infective Endocarditis-A Nationwide Database Study.Journal of clinical medicine · 2025Article
- Dual transcriptomic profiling ofmBio · 2025Article
- Article
- Evolving Standards in Prosthetic Heart Valve Assessment With Cardiovascular Imaging: Key Changes in the 2024 American Society of Echocardiography Guidelines.Structural heart : the journal of the Heart Team · 2025Review
- Reoperative surgery for early- and late-onset prosthetic valve endocarditis: temporal trends and outcomes.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Multimodality Imaging Approach to Infective Endocarditis: Current Opinion in Patients with Congenital Heart Disease.Journal of clinical medicine · 2025Review
- The role of multimodal imaging in the diagnosis of prosthetic valve and intracardiac device endocarditis: A review.The international journal of cardiovascular imaging · 2025Review
- Advancements and Challenges in the Management of Prosthetic Valve Endocarditis: A Review.Pathogens (Basel, Switzerland) · 2024Review
- Using machine learning to improve the diagnostic accuracy of the modified Duke/ESC 2015 criteria in patients with suspected prosthetic valve endocarditis - a proof of concept study.European journal of nuclear medicine and molecular imaging · 2024Article
- Diagnostic Benefit of Molecular Imaging in Patients Undergoing Heart Valve Surgery for Infective Endocarditis.Microorganisms · 2024Article
- Longitudinal Outcomes Following Mitral Valve Repair for Infective Endocarditis.Microorganisms · 2024Article
- Trends of Infective Endocarditis at Two Teaching Hospitals: A 12-Year Retrospective Cohort Study in Rio de Janeiro, Brazil.Tropical medicine and infectious disease · 2023Article
- Contemporary Features and Management of Endocarditis.Diagnostics (Basel, Switzerland) · 2023Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe incidence of infective endocarditis (IE) is increasing, as is the insertion of prosthetic heart valves. We aimed to examine nationwide temporal trends in the incidence of IE in patients with a prosthetic heart valve in Denmark from 1999 to 2018.
methodsUsing the Danish nationwide registries, we identified patients who underwent heart valve implantation (for other reasons than IE) between 1999 and 2018. Crude incidence rates of IE per 1000 person-years (PY) were computed in 2-year intervals. IE incidences were compared using sex-adjusted and age-adjusted incidence rate ratios (IRR) using Poisson regression across calendar periods (1999-2003, 2004-2008, 2009-2013, and 2014-2018).
resultsWe identified 26 604 patients with first-time prosthetic valve implantation (median age 71.7 years (IQR 62.7-78.0), 63% males). The median follow-up time was 5.4 years (IQR 2.4-9.6). Patients in the time period 2014-2018 were older (median age of 73.9 years (66.2:80.3)), and with a higher burden of comorbidities compared with the time period 1999-2003 (median age of 67.9 years (58.3:74.5)) at the time of implantation. A total of 1442 (5.4%) patients developed IE. The lowest IE incidence rate was 5.4/1000 PY (95% CI 3.9 to 7.4) in 2001-2002, and the highest incidence rate was 10.0/1000 PY (95% CI 8.8 to 11.1) in 2017-2018 with an unadjusted increase during the study period (p=0.003). We found an adjusted IRR of 1.04 (95% CI 1.02 to 1.06) (p<0.0007) per two calendar-years increments. Age-adjusted IRR for men were 1.04 (95% CI 1.01 to 1.07) (p=0.002) per two calendar years increment, and for women 1.03 (95% CI 0.99 to 1.07) (p=0.12), with p=0.32 for interaction.
conclusionIn Denmark, the incidence of IE increased during the last 20 years in patients with prosthetic heart valves.
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