Bullous eruptions in transient abnormal myelopoiesis with normal phenotype.

Madhusudhan Demahalli Shivamallappa, Anna Mullins, Kathryn Browning Carmo

Open access · greenAbstract readCase Reports

In one paragraph

Article in BMJ case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Congenital Thrombocytosis, Hepatosplenomegaly, and Rash in a Term Neonate.AJP reports · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Madhusudhan Demahalli ShivamallappaGRACE NICU, Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID http://orcid.org/0000-0002-3336-886X

Anna MullinsOncology, Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Kathryn Browning CarmoNeonatal and Paediatric Emergency Transport Service, The Sydney Children's Hospitals Network Randwick and Westmead, Bankstown Aerodrome, New South Wales, Australia kath.carmo@nets.health.nsw.gov.au.ORCID http://orcid.org/0000-0002-1200-9016

Children's Hospital at Westmead · AURoyal Children's Hospital · AUSydney Children’s Hospitals Network · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous lesions are common manifestation of congenital leukaemia especially myeloid type with incidence of 25%-50% in reported cases. It is relatively rare in transient abnormal myelopoiesis (TAM) seen in trisomy 21 (~10%). The rashes seen in leukaemia and TAM are different. We report a case with a rare presentation of confluent bullous eruption in a phenotypically normal neonate with trisomy 21 restricted to haematopoietic blast cells. This rash resolved rapidly after low-dose cytarabine therapy with normalisation of total white cell counts. The risk of Down syndrome-associated myeloid leukaemia in such cases is still high (19%-23%) in first 5 years and rare thereafter.

Indexed as

Down SyndromeLeukemiaLeukemoid ReactionGATA1 Transcription FactorHumansPhenotypeGATA1 Transcription FactorDermatologyGenetic screening / counsellingNeonatal intensive care

Identifiers

PMID37028822

DOI10.1136/bcr-2022-251523

PMCPMC10083739

OpenAlexW4362697187

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.