Evidence map›Paper›PMID 37028583›Full record

ArticleBone2023

Induced pluripotent stem cell technology in bone biology.

Fahad K Kidwai, Ernesto Canalis, Pamela G Robey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Fahad K KidwaiSkeletal Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States of America.
Ernesto CanalisCenter for Skeletal Research, Orthopedic Surgery and Medicine, UConn Musculoskeletal Institute, UConn Health, Farmington, CT 06030-4037, United States of America.
Pamela G RobeySkeletal Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States of America. Electronic address: pamela.robey@nih.gov.
National Institute of Dental and Craniofacial Research · USNational Institutes of Health · USUConn Health · US

Funding

The role of stem cells in skeletal health and diseaseZIADE000380 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ROBEY, PAMELA G · 2009 to 2025
$30.6M
The role of post-natal skeletal stem cells in health and diseaseZ01DE000380 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ROBEY, PAMELA GEHRON · 1985 to 2008
$3.6M
The Skeleton of Lateral Meningocele SyndromeR01AR072987 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2018 to 2023
$2.2M
Mechanisms and Treatment of Hajdu Cheney SyndromeR01AR078149 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2021 to 2025
$1.8M
Targeting the Notch3 Mutation to Cure Lehman SyndromeR61AR076747 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2019 to 2020
$799k
Targeting the Notch3 Mutation to Cure Lehman SyndromeR33AR076747 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2022 to 2022
$411k
Intramural NIH HHS Z01 DE000380Intramural NIH HHS ZIA DE000380NIAMS NIH HHS R01 AR072987NIAMS NIH HHS R01 AR078149NIAMS NIH HHS R33 AR076747NIAMS NIH HHS R61 AR076747
6 · The paper itself

Abstract

Technologies on the development and differentiation of human induced pluripotent stem cells (hiPSCs) are rapidly improving, and have been applied to create cell types relevant to the bone field. Differentiation protocols to form bona fide bone-forming cells from iPSCs are available, and can be used to probe details of differentiation and function in depth. When applied to iPSCs bearing disease-causing mutations, the pathogenetic mechanisms of diseases of the skeleton can be elucidated, along with the development of novel therapeutics. These cells can also be used for development of cell therapies for cell and tissue replacement.

Indexed as

Induced Pluripotent Stem CellsBiologyCell DifferentiationHumansInduced pluripotent stem cells RModels of diseaseOsteogenic differentiationPluripotent stem cellsReprogramming

Identifiers

PMID37028583
PMCPMC10228209
OpenAlexW4362672255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.