ArticleCurrent biology : CB2023
Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- A gene-agnostic FACS technique to isolate stem cells inbioRxiv : the preprint server for biology · 2026Article
- Cellular and transcriptional trajectories of neural fate specification in sea anemone uncover two modes of adult neurogenesis.Nature communications · 2026Article
- Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity.Nature communications · 2025Article
- Single-nucleus profiling highlights the all-brain echinoderm nervous system.Science advances · 2025Article
- How Single-Cell Transcriptomics of Hydractinia Is Informing the Evolution of Cnidarian Sensory Systems.Integrative and comparative biology · 2025Review
- An updated and spatially validated somatic single-cell atlas ofbioRxiv : the preprint server for biology · 2025Article
- Article
- The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality.Nature communications · 2025Article
- A whole-body atlas of BMP signaling activity in an adult sea anemone.BMC biology · 2025Article
- Regeneration in the absence of canonical neoblasts in an early branching flatworm.Nature communications · 2025Article
- A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian.Science advances · 2025Article
- Apoptosis-dependent head development during metamorphosis of the cnidarian Hydractinia symbiolongicarpus.Developmental biology · 2024Article
- Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.Nature communications · 2024Article
- The emergence of Sox and POU transcription factors predates the origins of animal stem cells.Nature communications · 2024Article
- A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone.Nature communications · 2024Article
- Article
- Highly regenerative species-specific genes improve age-associated features in the adult Drosophila midgut.BMC biology · 2024Article
- Male Germ Cell Specification in Plants.International journal of molecular sciences · 2024Review
- Regeneration in the absence of canonical neoblasts in an early branching flatworm.bioRxiv : the preprint server for biology · 2024Article
- Annelids as models of germ cell and gonad regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In most animals, pluripotency is irreversibly lost post gastrulation. By this stage, all embryonic cells have already committed either to one of the somatic lineages (ectoderm, endoderm, or mesoderm) or to the germline. The lack of pluripotent cells in adult life may be linked to organismal aging. Cnidarians (corals and jellyfish) are an early branch of animals that do not succumb to age, but the developmental potential of their adult stem cells remains unclear. Here, we show that adult stem cells in the cnidarian Hydractinia symbiolongicarpus (known as i-cells) are pluripotent. We transplanted single i-cells from transgenic fluorescent donors to wild-type recipients and followed them in vivo in the translucent animals. Single engrafted i-cells self-renewed and contributed to all somatic lineages and gamete production, co-existing with and eventually displacing the allogeneic recipient's cells. Hence, a fully functional, sexually competent individual can derive from a single adult i-cell. Pluripotent i-cells enable regenerative, plant-like clonal growth in these animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.