ArticleImmunity2023
Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.
Open access · greenAbstract read
In one paragraph
Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
What it found
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Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
- Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8Nature communications · 2026Article
- Maternal antibodies regulate the establishment of murine oral and salivary mucosal immunity.Nature communications · 2026Article
- Conserved CD4Nature microbiology · 2026Article
- Cutaneous Dendritic Cells: Structure, Function and Immune Role.Biomedicines · 2026Review
- Article
- Beyond the skin barrier: commensalbioRxiv : the preprint server for biology · 2026Article
- Identification and Preliminary mRNA Validation of Key Genes Associated with Tolerogenic Dendritic Cells in Keloid Based on Transcriptome Data.Clinical, cosmetic and investigational dermatology · 2026Article
- Microbiota-directed therapies for atopic dermatitis: a three-tier framework for inflammation control, immune modulation, and microbiome restoration.Frontiers in immunology · 2026Review
- Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions.Frontiers in microbiology · 2026Review
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
- Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation.Immunological reviews · 2025Review
- Single-cell analysis reveals an important role of CD137L+ macrophages in the host response to uropathogenic Escherichia coli infection in the bladder.PLoS pathogens · 2025Article
- Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways.Cell reports · 2025Article
- Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer.Science immunology · 2025Article
- The human skin microbiome in health.Journal of the American Academy of Dermatology · 2025Review
- Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata.Journal of nanobiotechnology · 2025Article
- Spermidine restricts neonatal inflammation via metabolic shaping of polymorphonuclear myeloid-derived suppressor cells.The Journal of clinical investigation · 2025Article
- Conversation between skin microbiota and the host: from early life to adulthood.Experimental & molecular medicine · 2025Review
- RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Tissue-Resident Th2 Cells in Type 2 Immunity and Allergic Diseases.Immunological reviews · 2025Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Antonin WeckelUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA.
Miqdad O DhariwalaUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA.
Kevin LyUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA.
Victoria M TranUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA.
Oluwasunmisola T OjewumiUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA.
Julianne B RiggsUniversity of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA.
Jeanmarie R GonzalezUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA.
Laura R DwyerUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA.
Joy N OkoroUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA.
John M LeechUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA.
Margot S BacinoUniversity of California, San Francisco, Oral and Craniofacial Sciences Graduate Program, San Francisco, CA 94143, USA.
Grace D ChoUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, Los Angeles, Department of Infectious Diseases, Los Angeles, CA 90095, USA.
Geil MeranaUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA.
Niroshana AnandasabapathyDepartment of Dermatology, Meyer Cancer Center, Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA.
Yosuke KumamotoDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Tiffany C ScharschmidtUniversity of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA. Electronic address: tiffany.scharschmidt@ucsf.edu.
University of California, San Francisco · USUniversity of San Francisco · USLander Institute · ILRutgers, The State University of New Jersey · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MInterrogating unique DC adaptations to tissue to promote barrier immunity and toleranceR01AR080436 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Niroshana Anandasabapathy · 2022 to 2026
$3.5MFunctional Dissection of Regulatory Myeloid Cells in Microbe-Immune Crosstalk in SkinR01AR080034 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tiffany Crawford Scharschmidt · 2022 to 2026
$2.9MDecoding and harnessing microbial tuning of T cell responses in early lifeDP2AI144968 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHARSCHMIDT, TIFFANY CRAWFORD · 2018 to 2018
$2.4MBD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573kElucidating microbial and host mechanisms supporting early life immune imprinting by skin monocytesK99AR079554 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DHARIWALA, MIQDAD ONALI · 2021 to 2022
$178kNIAID NIH HHS DP2 AI144968NIAID NIH HHS T32 AI007334NIAMS NIH HHS K99 AR079554NIAMS NIH HHS R01 AR080034NIAMS NIH HHS R01 AR080436NIDDK NIH HHS P30 DK063720NIH HHS S10 OD021822
Abstract
Early-life establishment of tolerance to commensal bacteria at barrier surfaces carries enduring implications for immune health but remains poorly understood. Here, we showed that tolerance in skin was controlled by microbial interaction with a specialized subset of antigen-presenting cells. More particularly, CD301b
Indexed as
Dendritic CellsSkinAldehyde OxidoreductasesAnimalsHumansImmune ToleranceMiceT-Lymphocytes, RegulatoryAldehyde OxidoreductasesRALDH2 protein, mousecommensal bacteriacommensalsdendritic cellsearly-life immunityneonatal immunityregulatory T cellsretinoic acidskinStaphylococcus epidermidistolerance
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.