ArticleCell stem cell2023
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche.
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Article in Cell stem cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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0cells of the map it votes in
53citing papers in PubMed
18.4field-weighted citation impact, top 1% of its field
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Who cites it
53 citing papers in PubMed, 80 citations in OpenAlex.
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- ResolVI: addressing noise and bias in spatial transcriptomics.Nature methods · 2026Article
- An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts.Molecular systems biology · 2026Article
- Cellular crosstalk of fibroblast-myofibroblast transition in intestinal homeostasis and disease.Biomarker research · 2026Review
- Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026Review
- BMP4 cocktail promotes utricular progenitor reprogramming and vestibular functional recovery in adult mice.Journal of advanced research · 2026Article
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- Tissue and cellular spatiotemporal dynamics in colon aging.Nature biotechnology · 2026Article
- Current Status of Intestinal Stem Cell Research: Mechanisms, Intestinal Diseases, and Organoid Development.Cells · 2026Review
- Stromal BMP signalling maintains stem cell genome integrity and prevents gastric cancer initiation.Cell death & disease · 2026Article
- Establishment of a broiler jejunal organoid model based on optimized activators or optimized two-step media and its assessment.Poultry science · 2026Article
- Pathophysiology of colitis-associated colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- Article
- Dynamic Reprogramming of PDGFRA-Expressing Stromal Cells Facilitates WNT-Driven Transformation by Promoting a Fetal-Like State in the Intestinal Epithelium.Cancer research · 2026Article
- Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.iScience · 2026Article
- Topology Outweighs Stiffness: Self-Reinforced Cell Mechanotransduction via Multiaxial Curvature Engineering of Ultrasoft Hydrogels.ACS nano · 2026Article
- RNA-Seq Analysis of Ruminal Methane Emissions in Beef-on-Dairy Cattle: Evidence for Immune, Nervous, and Endocrine Pathway Involvement.Animals : an open access journal from MDPI · 2026Article
- The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt.Bulletin of mathematical biology · 2026Article
- Construction of Vascularized Intestinal Organoids Based on Scaffolds, Hydrogels, and 3D Printing Technologies and Their Applications in Drug Delivery.International journal of nanomedicine · 2026Review
- Decoding adenomyosis pathogenesis using an assembloid model.Science China. Life sciences · 2026Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Judith KraiczyDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Neil McCarthyDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Ermanno MalagolaDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA.
Guodong TieDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Shariq MadhaDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Dario BoffelliInstitute for Human Genetics and Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
Daniel E WagnerDepartment of Obstetrics, Gynecology and Reproductive Science and Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA.
Ramesh A ShivdasaniDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: ramesh_shivdasani@dfci.harvard.edu.
Brigham and Women's Hospital · USColumbia University Irving Medical Center · USDana-Farber Cancer Institute · USUniversity of California, San Francisco · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MIntestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5MThe roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironmentU01DK103147 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2014 to 2023
$5.4MUnderstanding stem cell heterogeneity and niche function in intestinal regeneration after irradiationU01DK103155 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUHA, CHANDAN, WANG, TIMOTHY CRAGIN · 2014 to 2023
$4.4MChromatin and transcriptional control of LGR5+ crypt base stem cellsU01DK103152 · NIDDK · DANA-FARBER CANCER INST · PI SHIVDASANI, RAMESH A · 2014 to 2023
$4.2MDevelopment and vascularity of intestinal mesenchymeR01DK121540 · NIDDK · DANA-FARBER CANCER INST · PI Ramesh A Shivdasani · 2019 to 2026
$3.3MLimited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3MMesenchymal regulation of fetal intestinal development and adult regenerationK01DK125639 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MCCARTHY, NEIL · 2020 to 2024
$692kNIDDK NIH HHS K01 DK125639NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK121540NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK103147NIDDK NIH HHS U01 DK103152NIDDK NIH HHS U01 DK103155NIDDK NIH HHS U24 DK085532
Abstract
Signals from the surrounding niche drive proliferation and suppress differentiation of intestinal stem cells (ISCs) at the bottom of intestinal crypts. Among sub-epithelial support cells, deep sub-cryptal CD81
Indexed as
Intestinal MucosaStem Cell NicheAnimalsCell DifferentiationCell ProliferationIntestinesMiceSignal Transductioncolonic cryptsintestinal crypt structure and functionintestinal stem cell nicheintestinal Wnt sourcemesenchymal niche compartmentsPDGFRA+ mesenchymal cellstrophocytes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.