ReviewCurrent opinion in immunology2023
Systems biology approaches to unravel lymphocyte subsets and function.
Review in Current opinion in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease.Frontiers in molecular biosciences · 2026Article
- [Expression of GPRC5D in newly diagnosed patients with multiple myeloma detected by flow cytometry and its prognostic value].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Establishment and validation of the prediction model based on lymphocyte subsets for acute kidney injury in sepsis patients.Frontiers in immunology · 2025Article
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Authors and funding
3 authors.
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Abstract
Single-cell technologies have revealed the extensive heterogeneity and complexity of the immune system. Systems biology approaches in immunology have taken advantage of the high-parameter, high-throughput data and analyzed immune cell types in a 'bottom-up' data-driven method. This approach has discovered previously unrecognized cell types and functions. Especially for human immunology, in which experimental manipulations are challenging, systems approach has become a successful means to investigate physiologically relevant contexts. This review focuses on the recent findings in lymphocyte biology, from their development, differentiation into subsets, and heterogeneity in their functions, enabled by these systems approaches. Furthermore, we review examples of the application of findings from systems approach studies and discuss how now to leave the rich dataset in the curse of high dimensionality.
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Registered trials
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