Evidence map›Paper›PMID 37028102›Full record

ArticleDrug and alcohol dependence2023

Incidence of suicide and self-harm among people with opioid use disorder and the impact of opioid agonist treatment: A retrospective data linkage study.

Samantha Colledge-Frisby, Nicola Jones, Louisa Degenhardt, Matthew Hickman, Prianka Padmanathan, Thomas Santo, Michael Farrell, Natasa Gisev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samantha Colledge-FrisbyNational Drug Research Institute, Curtin University, Perth, Australia; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia; The Burnet Institute, Melbourne, Australia. Electronic address: s.colledge@curtin.edu.au.
Nicola JonesNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.
Matthew HickmanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Prianka PadmanathanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Thomas SantoNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.
Michael FarrellNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.
Natasa GisevNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.

Funding

Integrating Multi-Assessment Protocols into PracticeR01DA014470 · NIDA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI GUYDISH, JOSEPH R · 2001 to 2003
$1.2M
Using existing data to understand and ameliorate risk in opioid agonist therapyR01DA044170 · NIDA · UNIVERSITY OF NEW SOUTH WALES · PI DEGENHARDT, LOUISA · 2017 to 2019
$641k
Medical Research Council MR/N00616X/1NIDA NIH HHS R01 DA014470NIDA NIH HHS R01 DA044170
6 · The paper itself

Abstract

backgroundRates of suicide and self-harm are elevated among people with opioid use disorder (OUD). This study examined incidence of self-harm and suicide among people who have entered OAT and assessed the impact of different OAT exposure periods on these events.

methodWe conducted a retrospective population-based cohort study of all OAT recipients (N = 45,664) in New South Wales, Australia (2002-2017), using linked administrative data. Incidence rates of self-harm hospitalisations and suicide deaths were estimated per 1000 person-years (PY). The first 28 days of an OAT episode, ≥ 29 days on OAT, the first 28 days off OAT, and ≥ 29 days off OAT (maximum four years post-OAT) were exposure periods. Poisson regression models with generalised estimating equations estimated the adjusted incidence rate ratios (ARR) of self-harm and suicide by OAT exposure periods, adjusting for covariates.

resultsThere were 7482 hospitalisations (4148 individuals) for self-harm and 556 suicides, equating to incidence rates of 19.2 (95% confidence intervals [CI]=18.8-19.7) and 1.0 (95%CI=0.9-1.1) per 1000 PY, respectively. Opioid overdose was implicated in 9.6% of suicides and 28% of self-harm hospitalisations. Compared to ≥ 29 days on OAT, the incidence rate of suicide was elevated in the 28 days following OAT cessation (ARR=17.4 [95%CI=11.7-25.9]), and the rate of self-harm hospitalisations was elevated during the first 28 days of OAT (ARR=2.2 [95%CI=1.9-2.6]) and the 28 days after leaving OAT (ARR=2.7 [95%CI=2.3-3.2]).

conclusionsOAT may reduce suicide and self-harm risk among people with OUD; however, OAT initiation and cessation are critical periods for targeting self-harm and suicide prevention interventions.

Indexed as

Opioid-Related DisordersSelf-Injurious BehaviorSuicideAnalgesics, OpioidCohort StudiesHumansIncidenceOpiate Substitution TreatmentRetrospective StudiesAnalgesics, OpioidOpioid agonist treatmentOpioid use disorderSelf-harmSuicide

Identifiers

PMID37028102
PMCPMC10225170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.