Evidence map›Paper›PMID 37028004›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2023

SARS-CoV-2 molecular testing and whole genome sequencing following RNA recovery from used BinaxNOW COVID-19 antigen self tests.

Phuong-Vi Nguyen, Ludy Registre Carmola, Ethan Wang, Leda Bassit, Anuradha Rao, Morgan Greenleaf, Julie A Sullivan, Greg S Martin, Wilbur A Lam, Jesse J Waggoner and 1 more

Abstract read
In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Phuong-Vi NguyenEmory University Department of Medicine, Atlanta, GA, USA; Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
Ludy Registre CarmolaEmory University Department of Pathology and Laboratory Medicine, Atlanta, GA, USA.
Ethan WangAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA; Emory University Department of Pathology and Laboratory Medicine, Atlanta, GA, USA.
Leda BassitEmory University Department of Pathology and Laboratory Medicine, Atlanta, GA, USA; Laboratory of Biochemical Pharmacology, Emory University, Atlanta, GA, USA.
Anuradha RaoAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA; Emory University Department of Pediatrics, Atlanta, GA, USA.
Morgan GreenleafAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
Julie A SullivanAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
Greg S MartinEmory University Department of Medicine, Atlanta, GA, USA; Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
Wilbur A LamAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA; Emory University Department of Pediatrics, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Jesse J WaggonerEmory University Department of Medicine, Atlanta, GA, USA; Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA. Electronic address: jjwaggo@emory.edu.
Anne PiantadosiEmory University Department of Medicine, Atlanta, GA, USA; Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA; Emory University Department of Pathology and Laboratory Medicine, Atlanta, GA, USA.

Funding

Technology Training and Dissemination CoreU54EB027690 · NIBIB · EMORY UNIVERSITY · PI Wilbur A Lam, GREGORY S MARTIN · 2018 to 2026
$96.1M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
NCATS NIH HHS UL1 TR002378
6 · The paper itself

Abstract

Widespread use of over-the-counter rapid diagnostic tests for SARS-CoV-2 has led to a decrease in availability of clinical samples for viral genomic surveillance. As an alternative sample source, we evaluated RNA isolated from BinaxNOW swabs stored at ambient temperature for SARS-CoV-2 rRT-PCR and full viral genome sequencing. 81 of 103 samples (78.6%) yielded detectable RNA, and 46 of 57 samples (80.7 %) yielded complete genome sequences. Our results illustrate that SARS-CoV-2 RNA extracted from used Binax test swabs provides an important opportunity for improving SARS-CoV-2 genomic surveillance, evaluating transmission clusters, and monitoring within-patient evolution.

Indexed as

COVID-19SARS-CoV-2HumansMolecular Diagnostic TechniquesRNA, ViralWhole Genome SequencingRNA, ViralCOVID-19Rapid testRT-PCRSARS-CoV-2Sequencing

Identifiers

PMID37028004
PMCPMC10036152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.