Evidence map›Paper›PMID 37027363›Full record

Observational studyPloS one2023

Drug-related problems in hypertension and gestational diabetes mellitus: A hospital cohort.

Priscilla Karilline Vale Bezerra, Jéssica Escorel Chaves Cavalcanti, Solimar Ribeiro Carlete Filho, Sarah Dantas Viana Medeiros, Antonio Gouveia Oliveira, Rand Randall Martins

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Priscilla Karilline Vale BezerraGraduate Program of Pharmaceutical Science, Health Science Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Jéssica Escorel Chaves CavalcantiGraduate Program in Sciences Applied to Women's Health, Maternidade Escola Januário Cicco, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Solimar Ribeiro Carlete FilhoPharmacy Department, Health Science Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Sarah Dantas Viana MedeirosSchool Maternity Januário Cicco, Health Science Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Antonio Gouveia OliveiraGraduate Program of Pharmaceutical Science, Health Science Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Rand Randall MartinsGraduate Program of Pharmaceutical Science, Health Science Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID 0000-0001-9668-0482
Universidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize the drug-related problems (DRPs) in high-risk pregnant women with hypertension and gestational diabetes mellitus according to frequency, type, cause, and factors associated with their occurrence in the hospital setting. METHODOLOGY: This is an observational, longitudinal, prospective study that included 571 hospitalized pregnant women with hypertension and gestational diabetes mellitus using at least one medication. DRPs were classified according to the Classification for Drug-Related Problems (PCNE V9.00). In addition to descriptive statistics, a univariate and multivariate logistic regression model was employed to determine the factors associated with the DRPs.

resultsA total of 873 DRPs were identified. The most frequent DRPs were related to therapeutic ineffectiveness (72.2%) and occurrence of adverse events (27.0%) and the main drugs involved were insulins and methyldopa. These were followed in the first five days of treatment by: the ineffectiveness of insulin (24.6%), associated with underdosage (12.9%) or insufficient frequency of administration (9.5%) and methyldopa associated with the occurrence of adverse reactions (40.2%) in the first 48h. Lower maternal age (OR 0.966, 95% CI 0.938-0.995, p = 0.022), lower gestational age (OR 0.966, 95% CI 0.938-0.996, p = 0.026), report of drug hypersensitivity (OR 2.295, 95% CI 1.220-4.317, p = 0.010), longer treatment time (OR 1.237, 95% CI: 1.147-1.333, p = 0.001) and number of prescribed medications (OR 1.211, 95% CI: 0.240-5.476, p = 0.001) were risk factors for occurrence of DRPs.

conclusionDRPs are frequent in pregnant women with hypertension and gestational diabetes mellitus, and they are mainly related to therapeutic ineffectiveness and the occurrence of adverse events.

Indexed as

Diabetes, GestationalDrug-Related Side Effects and Adverse ReactionsHypertensionFemaleHospitalsHumansInsulinMethyldopaPregnancyProspective StudiesInsulinMethyldopa

Identifiers

PMID37027363
PMCPMC10081748
OpenAlexW4362693010

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.