Evidence map›Paper›PMID 37027338›Full record

ArticleEnvironmental health perspectives2023

Amniogenesis in Human Amniotic Sac Embryoids after Exposures to Organophosphate Flame Retardants.

Chenke Xu, Chenhao Zhang, Yanan Liu, Haojia Ma, Feifan Wu, Yingting Jia, Jianying Hu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chenke XuMOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.
Chenhao ZhangMOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.
Yanan LiuMOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.
Haojia MaMOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.
Feifan WuMOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.
Yingting JiaMOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.
Jianying HuMOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, China.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmniogenesis is a key event in biochemical pregnancy, and its failure may result in human embryonic death. However, whether and how environmental chemicals affect amniogenesis remain largely unknown.

objectivesThe objective of the present study was to screen chemicals that may disrupt amniogenesis in an amniotic sac embryoid model and to investigate the potential mechanism of amniogenesis failure, with a focus on organophosphate flame retardants (OPFRs).

methodsThis study developed a high-throughput toxicity screening assay based on transcriptional activity of octamer-binding transcription factor 4 (

resultsEight positive hits exhibiting

conclusionThe amniotic sac embryoid models suggested that OPFRs disrupted amniogenesis likely by inhibiting the

Indexed as

Flame RetardantsOrganophosphatesBiphenyl CompoundsFemaleHumansPhosphatesPregnancybiphenylBiphenyl CompoundsFlame RetardantsOrganophosphatesPhosphates

Identifiers

PMID37027338
PMCPMC10081692
OpenAlexW4362692826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.