Evidence map›Paper›PMID 37026482›Full record

ArticleJournal of neuroscience research2023

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome.

Michael Mykins, Dana Layo-Carris, Logan Reid Dunn, David Wilson Skinner, Alexandra Hart McBryar, Sarah Perez, Trinity Rose Shultz, Andrew Willems, Billy You Bun Lau, Tian Hong and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroscience research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pubertal development is unaffected in femalemicroPublication biology · 2026
    Article
  6. Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  7. Sensory experiences questionnaire unravels differences in sensory profiles between MECP2-related disorders.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  8. Article
  9. Caregiver Perspectives on Pain Sensitivity and Pain Experience in Rett Syndrome.Canadian journal of pain = Revue canadienne de la douleur · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Michael MykinsDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0003-3467-5308
Dana Layo-CarrisDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0001-7009-0652
Logan Reid DunnDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-2147-5502
David Wilson SkinnerDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.
Alexandra Hart McBryarDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.
Sarah PerezDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.
Trinity Rose ShultzDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.
Andrew WillemsDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-7927-0745
Billy You Bun LauDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-2380-5341
Tian HongDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-8212-7050
Keerthi KrishnanDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-0858-4624
University of Tennessee at Knoxville · US

Funding

Postdoctoral Training Program in Genomic MedicineT32HG009495 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Katherine L. Nathanson, Bogdan Pasaniuc · 2017 to 2026
$4.2M
Mathametical modeling of cell fate transitions regulated by ultra-feedbacksR01GM140462 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI HONG, TIAN · 2020 to 2022
$600k
Role of Piriform Cortex Perineuronal Nets in Mouse Social Communication.R15MH124042 · NIMH · UNIVERSITY OF TENNESSEE KNOXVILLE · PI KRISHNAN, KEERTHI · 2020 to 2020
$451k
NHGRI NIH HHS T32 HG009495NIGMS NIH HHS R01 GM140462NIMH NIH HHS R15 MH124042NIMH NIH HHS R15MH124042
6 · The paper itself

Abstract

Rett syndrome is characterized by an early period of typical development and then, regression of learned motor and speech skills in girls. Loss of MECP2 protein is thought to cause Rett syndrome phenotypes. The specific underlying mechanisms from typical developmental trajectory to regression features throughout life are unclear. Lack of established timelines to study the molecular, cellular, and behavioral features of regression in female mouse models is a major contributing factor. Due to random X-chromosome inactivation, female patients with Rett syndrome and female mouse models for Rett syndrome (Mecp2

Indexed as

Methyl-CpG-Binding Protein 2Rett SyndromeAnimalsCerebral CortexDisease Models, AnimalFemaleMicePhenotypeMethyl-CpG-Binding Protein 2adolescence and adulthoodbarrel cortexfemale micematernal behaviorMECP2mosaicismperineuronal netsRett syndrometactile sensationX-linked disorders

Identifiers

PMID37026482
PMCPMC10332853
OpenAlexW4362693151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.