Evidence map›Paper›PMID 37026145›Full record

ArticleFrontiers in public health2023

Wastewater pandemic preparedness: Toward an end-to-end pathogen monitoring program.

Justin R Clark, Austen Terwilliger, Vasanthi Avadhanula, Michael Tisza, Juwan Cormier, Sara Javornik-Cregeen, Matthew Clayton Ross, Kristi Louise Hoffman, Catherine Troisi, Blake Hanson and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Wastewater Metagenomic Virome Analysis of the 2026 World Cup in Texas.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Wastewater Parvovirus B19 Signal Amid Rising Maternal Cases.medRxiv : the preprint server for health sciences · 2025
    Article
  9. Article
  10. Article
  11. Characterization of methicillin resistantOne health (Amsterdam, Netherlands) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Justin R ClarkTAILOR Labs, Baylor College of Medicine, Houston, TX, United States.
Austen TerwilligerTAILOR Labs, Baylor College of Medicine, Houston, TX, United States.
Vasanthi AvadhanulaDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Michael TiszaDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Juwan CormierDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Sara Javornik-CregeenDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Matthew Clayton RossDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Kristi Louise HoffmanDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Catherine TroisiUTHealth Houston School of Public Health, Houston, TX, United States.
Blake HansonUTHealth Houston School of Public Health, Houston, TX, United States.
Joseph PetrosinoDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
John BalliewEl Paso Water Utility, El Paso, TX, United States.
Pedro A PiedraDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Janelle RiosUTHealth Houston School of Public Health, Houston, TX, United States.
Jennifer DeeganTexas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States.
Cici BauerUTHealth Houston School of Public Health, Houston, TX, United States.
Fuqing WuUTHealth Houston School of Public Health, Houston, TX, United States.
Kristina D MenaUTHealth Houston School of Public Health, Houston, TX, United States.
Eric BoerwinkleUTHealth Houston School of Public Health, Houston, TX, United States.
Anthony W MaressoTAILOR Labs, Baylor College of Medicine, Houston, TX, United States.
Baylor College of Medicine · USPublic Health Institute · USCenter for Human Genetics · USUniversity of Texas Health Science Center at Dallas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, molecular sciences, temporal-geospatial analytics, epidemiology and medical, and governmental and public health messaging, all of which present their own caveats. Here, we outline a framework for an integrated, state-wide, end-to-end human pathogen monitoring program using wastewater to track viral PPPs.

Indexed as

COVID-19WastewaterHumansPandemicsPublic HealthSARS-CoV-2Wastewaterdetectionearly warning systemepidemiologicpathogenspublic healthviruswastewater

Identifiers

PMID37026145
PMCPMC10070845
OpenAlexW4328112113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.