ArticleFrontiers in public health2023
Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Global Biobank Meta-analysis Initiative: How can global health benefit by its use?Journal of global health · 2023Pooled it
- Environmental Contaminants and Osteoporosis-Related Outcomes: A Systematic Review and Meta-Analysis.Toxics · 2026Review
- Relationship between short-term exposure to ambient sulfur dioxide and length of hospital stay after surgery for osteoporotic fractures: a distributed lag non-linear analysis.BMC public health · 2026Observational
- Study on the Potential Molecular Mechanisms of Sodium Dehydroacetate (Na-DHA) Interfering With Bone Metabolism and Inducing Osteoporosis Based on Network Toxicology, Molecular Docking, and In Vitro Experimental Validation.Food science & nutrition · 2026Article
- Association of high-density lipoprotein with P1NP and β-CTX in hospitalized patients with osteoporotic fractures: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Social determinants of vulnerability to nitrogen oxide- and sulfur dioxide-related bone damage among postmenopausal women in the United States.Frontiers in public health · 2026Article
- Investigating the association between urban rural classification with fragility fractures and bone density in the UK: evidence from a large observational clinical cohort.Rheumatology advances in practice · 2026Article
- Association of fine particulate matter and wet-bulb globe temperature with depression incidence in a community-based longitudinal study.Scientific reports · 2025Article
- Metabolomic evaluation of air pollution-related bone damage and potential mediation in Women's Health Initiative participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Short-term air pollution and fracture admissions in Beijing.Frontiers in public health · 2025Article
- Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study.Frontiers in toxicology · 2025Article
- Association of Fine Particulate Matter (PM2.5) and Wet-Bulb Globe Temperature (WBGT) with Osteoporosis Incidence: A Nationwide Prospective Cohort Study.International journal of medical sciences · 2025Article
- Air Pollution and Osteoporosis.Current osteoporosis reports · 2024Review
- Exposure to air pollution might decrease bone mineral density and increase the prevalence of osteoporosis: a Mendelian randomization study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- CircCOX6A1 suppresses osteogenic differentiation and aggravates osteoporosis via miR-512-3p/DYRK2 axis.Molecular biology reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To reveal relationship between air pollution exposure and osteoporosis (OP) risk. Methods: Based on large-scale data from the UK Biobank, we evaluated the relationship between OP risk and several air pollutants. Then air pollution scores (APS) were constructed to assess the combined effects of multiple air pollutants on OP risk. Finally, we constructed a genetic risk score (GRS) based on a large genome-wide association study of femoral neck bone mineral density and assessed whether single or combined exposure to air pollutants modifies the effect of genetic risk on OP and fracture risk. Results: PM Conclusions: We found that exposure to air pollution, individually or jointly, could improve the risk of developing OP and fractures, and increased the risk by interacting with genetic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.