Evidence map›Paper›PMID 37026013›Full record

ArticleFrontiers in immunology2023

Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters.

Hannah A D King, Vincent Dussupt, Letzibeth Mendez-Rivera, Bonnie M Slike, Ursula Tran, Nathan D Jackson, Erica Barkei, Michelle Zemil, Emily Tourtellott-Fogt, Caitlin H Kuklis and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Hannah A D KingUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Vincent DussuptUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Letzibeth Mendez-RiveraUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Bonnie M SlikeUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Ursula TranUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Nathan D JacksonUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Erica BarkeiVeterinary Pathology Branch, WRAIR, Silver Spring, MD, United States.
Michelle ZemilUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Emily Tourtellott-FogtUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Caitlin H KuklisViral Diseases Branch, WRAIR, Silver Spring, MD, United States.
Sandrine SomanViral Diseases Branch, WRAIR, Silver Spring, MD, United States.
Aslaa AhmedViral Diseases Branch, WRAIR, Silver Spring, MD, United States.
Maciel PortoBIOQUAL, Inc., Rockville, MD, United States.
Christopher KitajewskiBIOQUAL, Inc., Rockville, MD, United States.
Brittany SpenceBIOQUAL, Inc., Rockville, MD, United States.
Dalia BenetieneBIOQUAL, Inc., Rockville, MD, United States.
Lindsay WieczorekUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Swagata KarBIOQUAL, Inc., Rockville, MD, United States.
Gregory GromowskiViral Diseases Branch, WRAIR, Silver Spring, MD, United States.
Victoria R PolonisUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Shelly J KrebsUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Kayvon ModjarradEmerging Infectious Diseases Branch, WRAIR, Silver Spring, MD, United States.
Diane L BoltonUS Military HIV Research Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Henry M. Jackson Foundation · USBioqual · USWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antibody therapeutic strategies have served an important role during the COVID-19 pandemic, even as their effectiveness has waned with the emergence of escape variants. Here we sought to determine the concentration of convalescent immunoglobulin required to protect against disease from SARS-CoV-2 in a Syrian golden hamster model. Methods: Total IgG and IgM were isolated from plasma of SARS-CoV-2 convalescent donors. Dose titrations of IgG and IgM were infused into hamsters 1 day prior to challenge with SARS-CoV-2 Wuhan-1. Results: The IgM preparation was found to have ~25-fold greater neutralization potency than IgG. IgG infusion protected hamsters from disease in a dose-dependent manner, with detectable serum neutralizing titers correlating with protection. Despite a higher Discussion: This study adds to the growing body of literature that demonstrates neutralizing IgG antibodies are important for protection from SARS-CoV-2 disease, and confirms that polyclonal IgG in sera can be an effective preventative strategy if the neutralizing titers are sufficiently high. In the context of new variants, against which existing vaccines or monoclonal antibodies have reduced efficacy, sera from individuals who have recovered from infection with the emerging variant may potentially remain an efficacious tool.

Indexed as

COVID-19SARS-CoV-2AnimalsAntibodies, NeutralizingCricetinaeHumansImmunoglobulin GMesocricetusPandemicsSurvivorsAntibodies, NeutralizingImmunoglobulin GantibodyhamsterIgGIgMpassive transferSARS-CoV-2

Identifiers

PMID37026013
PMCPMC10070741
OpenAlexW4328115536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.