Evidence map›Paper›PMID 37025998›Full record

ArticleFrontiers in immunology2023

Inflammation markers and the risk of hypertension in people living with HIV.

Hui Ou-Yang, Hai-Yan Fu, Yu Luo, Zhao-Yuan Xu, Jun Liu, Rui Gao, Jin-Yu Duan, Ya-Chao Mao, Hong-Juan Li, Ying-Rong Du

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Observational
  7. Article
  8. Anti-inflammatory effects ofScientific reports · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Inflammatory Biomarkers in Hypertension.Current medicinal chemistry · 2025
    Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hui Ou-YangDepartment of Cardiovascular Medicine, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Hai-Yan FuDepartment of Hospice Care, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Yu LuoDepartment of Hospice Care, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Zhao-Yuan XuDepartment of Cardiovascular Medicine, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Jun LiuDepartment of Infectious Diseases, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Rui GaoDepartment of Infectious Diseases, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Jin-Yu DuanDepartment of Infectious Diseases, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Ya-Chao MaoDepartment of Cardiovascular Medicine, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Hong-Juan LiDepartment of Hospice Care, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Ying-Rong DuDepartment of Cardiovascular Medicine, The Third People's Hospital of Kunming, Yunnan Clinical Medicine Center for Infectious Diseases, Kunming, China.
Kunming Third People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The incidence of hypertension is high in people living with HIV (PLWH). High-sensitivity C-reactive protein (hsCRP), systemic inflammation response index (SIRI), and neutrophil-to-monocyte ratio (NMR) are considered economic and convenient parameters that reflect the levels of inflammation in patients. Our aim was to explore whether indirect inflammation markers are associated with hypertension in PLWH. Methods: This was a case-control study. The case group (hypertension) comprised PLWH with hypertension, and the control group (non-hypertension) comprised sex- and age-(± 3 years)-matched PLWH without hypertension. Demographic parameters, hsCRP, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune- inflammation index (SII), SIRI, lymphocyte-to-monocyte ratio (LMR), platelet-to-neutrophil ratio (PNR), platelet-to-monocyte ratio (PMR), NMR, time to HIV diagnosis, antiretroviral therapy (ART) duration, recent CD4 Results: In the hypertension group, body mass index (BMI), hsCRP, NLR, SII, SIRI, NMR, time to HIV diagnosis, ART duration, CD4 Conclusions: We identified positive associations between inflammation markers hsCRP, SIRI, NMR and hypertensive risk in PLWH. Alleviating inflammation may help control or delay the occurrence of hypertension in PLWH.

Indexed as

HIV InfectionsHypertensionAnti-Retroviral AgentsCase-Control StudiesC-Reactive ProteinHumansInflammationRNAAnti-Retroviral AgentsC-Reactive ProteinRNAAIDShigh-sensitivity C-reactive proteinHIVhypertensioninflammation markers

Identifiers

PMID37025998
PMCPMC10071023
OpenAlexW4328118229

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.