Management of neuropsychiatric adverse events in a prostate cancer patient undergoing chimeric antigen receptor T-cell immunotherapy (a phase I clinical trial): A case report.

Ruijin Tang, Qiong Wang, Jing Han, Ming Shi

Open access · goldAbstract readCase Reports

In one paragraph

Article in Asia-Pacific journal of oncology nursing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 98% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ruijin TangSchool of Nursing, Xuzhou Medical University, Xuzhou, China.

Qiong WangDepartment of Urology, Xuzhou Medical University Affiliated Hospital, Xuzhou, China.

Jing HanSchool of Nursing, Xuzhou Medical University, Xuzhou, China.

Ming ShiNational and Local Joint Engineering Laboratory of Tumor Biotherapy, The First Clinical College of Xuzhou Medical University, Xuzhou, China.

Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In previous clinical trials, chimeric antigen receptor T-cell immunotherapy has shown preliminary efficacy in patients with malignant solid tumors. However, the occurrence of adverse events, particularly neuropsychiatric adverse events (eg, anxiety) and cognitive dysfunction, during the course of treatment may reduce patient compliance and pose a threat to their safety. Nurses are in a unique position to promptly identify and manage such complications, thereby facilitating early diagnosis and treatment, as well as improving clinical and patient outcomes. Moreover, nurses can promote compliance through the provision of psychological support to patients.

Indexed as

AnxietyCancer careCAR T-cell immunotherapyPsychological supportSide effects

Identifiers

PMID37025985

DOI10.1016/j.apjon.2023.100211

PMCPMC10070376

OpenAlexW4322761381

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.