Evidence map›Paper›PMID 37025950›Full record

ArticleMolecular therapy. Methods & clinical development2023

Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy.

Gergely Imre, Bertalan Takács, Erik Czipa, Andrea Bakné Drubi, Gábor Jaksa, Dóra Latinovics, Andrea Nagy, Réka Karkas, Liza Hudoba, Bálint Márk Vásárhelyi and 16 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 6 institutions in 3 countries.

Gergely ImreLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Bertalan TakácsHCEMM-BRC Mutagenesis and Carcinogenesis Research Group, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Erik CzipaDepartment of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
Andrea Bakné DrubiLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Gábor JaksaDelta Bio 2000 Ltd., Szeged, Hungary.
Dóra LatinovicsSeqomics Biotechnology Ltd, Mórahalom, Hungary.
Andrea NagyLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Réka KarkasLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Liza HudobaLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Bálint Márk VásárhelyiLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Gabriella Pankotai-BodóInstitute of Pathology, University of Szeged, Szeged, Hungary.
András BlastyákLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Zoltán HegedűsLaboratory of Bioinformatics, Biological Research Centre, Szeged, Hungary.
Péter GermánLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Balázs BálintLaboratory of Fungal Genomics and Evolution, Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.
Khaldoon Sadiq Ahmed AbdullahLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Anna Georgina KopaszLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Anita KovácsWenzhou-Kean University, Wenzhou, China.
László G NagyLaboratory of Fungal Genomics and Evolution, Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.
Farkas SükösdInstitute of Pathology, University of Szeged, Szeged, Hungary.
Lajos PintérDelta Bio 2000 Ltd., Szeged, Hungary.
Thomas RülickeInstitute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Vienna, Austria.
Endre BartaDepartment of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
István NagySeqomics Biotechnology Ltd, Mórahalom, Hungary.
Lajos HaracskaHCEMM-BRC Mutagenesis and Carcinogenesis Research Group, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
Lajos MátésLaboratory of Cancer Genome Research, Institute of Genetics, Biological Research Centre, Szeged, Hungary.
HUN-REN Szegedi Biológiai Kutatóközpont · HUUniversity of Szeged · HUUniversity of Debrecen · HUChinese Academy of Sciences · CNSeqOmics Biotechnology (Hungary) · HUUniversity of Veterinary Medicine Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA transposon-based gene delivery vectors represent a promising new branch of randomly integrating vector development for gene therapy. For the side-by-side evaluation of the

Indexed as

DNA transposongene therapypiggyBacprolonged transpositional activitySleeping Beautytyrosinemia type I

Identifiers

PMID37025950
PMCPMC10070360
OpenAlexW4324030895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.