Evidence map›Paper›PMID 37025529›Full record

ArticleSurgical neurology international2023

Spinal cord epidural stimulation for motor and autonomic function recovery after chronic spinal cord injury: A case series and technical note.

Maxwell Boakye, Tyler Ball, Nicholas Dietz, Mayur Sharma, Claudia Angeli, Enrico Rejc, Steven Kirshblum, Gail Forrest, Forest W Arnold, Susan Harkema

Abstract read
In one paragraph

Article in Surgical neurology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maxwell BoakyeDepartment of Neurosurgery, University of Louisville, Louisville, Kentucky.
Tyler BallDepartment of Neurosurgery, Vanderbilt University, Nashville.
Nicholas DietzDepartment of Neurosurgery, University of Louisville, Louisville, Kentucky.
Mayur SharmaDepartment of Neurosurgery, University of Louisville, Louisville, Kentucky.
Claudia AngeliDepartment of Neurosurgery, University of Louisville, Louisville, Kentucky.
Enrico RejcDepartment of Neurosurgery, University of Louisville, Louisville, Kentucky.
Steven KirshblumDepartment of Physical Medicine Rehabilitation, Rutgers, Newark, New Jersey.
Gail ForrestDepartment of Physical Medicine Rehabilitation, Rutgers, Newark, New Jersey.
Forest W ArnoldDepartment of Infectious Diseases, University of Louisville, Louisville, United States.
Susan HarkemaDepartment of Neurosurgery, University of Louisville, Louisville, Kentucky.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traumatic spinal cord injury (tSCI) is a debilitating condition, leading to chronic morbidity and mortality. In recent peer-reviewed studies, spinal cord epidural stimulation (scES) enabled voluntary movement and return of over-ground walking in a small number of patients with motor complete SCI. Using the most extensive case series ( Methods: This prospective study occurred at the University of Louisville from 2009 to 2020. scES interventions began 2-3 weeks after surgical implantation of the scES device. Perioperative complications were recorded as well as long-term complications during training and device related events. QOL outcomes and patient satisfaction were evaluated using the impairment domains model and a global patient satisfaction scale, respectively. Results: Twenty-five patients (80% male, mean age of 30.9 ± 9.4 years) with chronic motor complete tSCI underwent scES using an epidural paddle electrode and internal pulse generator. The interval from SCI to scES implantation was 5.9 ± 3.4 years. Two participants (8%) developed infections, and three additional patients required washouts (12%). All participants achieved voluntary movement after implantation. A total of 17 research participants (85%) reported that the procedure either met ( Conclusion: scES in this series was safe and achieved numerous benefits on motor and cardiovascular regulation and improved patient-reported QOL in multiple domains, with a high degree of patient satisfaction. The multiple previously unreported benefits beyond improvements in motor function render scES a promising option for improving QOL after motor complete SCI. Further studies may quantify these other benefits and clarify scES's role in SCI patients.

Indexed as

Epidural stimulationFunctional recoveryNeuromodulationRehabilitationSpinal cord injurySpinal cord stimulationSpinal surgeryTechnical note

Identifiers

PMID37025529
PMCPMC10070319

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.