ArticleFrontiers in sports and active living2023
Arthrogenic muscle inhibition after anterior cruciate ligament injury: Injured and uninjured limb recovery over time.
Article in Frontiers in sports and active living, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Changes in Quadriceps Force Control and Torque Quality Following Anterior Cruciate Ligament Injury and Reconstruction: Associations with Functional Performance-A Systematic Review and Meta-Analysis.Sports medicine - open · 2026Pooled it
- Effectiveness of strength-oriented rehabilitation interventions as a non-pharmacologic rehabilitation strategy for knee function after anterior cruciate ligament reconstruction: a three-level meta-analysis.Frontiers in medicine · 2026Pooled it
- Cross-education effects of healthy-side lower-limb strength training on neuromuscular function recovery following anterior cruciate ligament reconstruction: a randomized controlled trial.Journal of orthopaedic surgery and research · 2026Trial
- Disrupted sensorimotor control after ACL injury: from mechanoreceptor degeneration to neuroplasticity-oriented rehabilitation.Annals of medicine · 2026Review
- Structural determinants of quadriceps atrophy following ACL injury: Evidence for fibre atrophy without fibre loss or overt peripheral denervation.The Journal of physiology · 2026Article
- Association Between Interlimb Asymmetry in Normalized Vastus Medialis sEMG Amplitude and Functional Mobility in Patients with Post-Traumatic Knee Contracture: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- FIRM-P separates knee phenotype from patient context in anterior cruciate ligament-related instability: A conceptual framework integrating arthrogenic muscle inhibition as a cross-domain modifier.Journal of experimental orthopaedics · 2026Article
- Recovery of Walking Function After ACL Reconstruction of the Knee Joint: A Non-Randomized Study and Mixed Cross-Sectional Comparison of Postoperative Time Groups.Journal of clinical medicine · 2026Article
- Biomechanical asymmetry during side-cutting is associated with lower limb muscle strength after anterior cruciate ligament reconstruction.BMC musculoskeletal disorders · 2026Article
- Isokinetic Strength Recovery and Fear of Re-Injury After ACL Reconstruction in Male Soccer Players: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Exploratory EEG-TMS Study Reveals Altered Behavioral Function in Individuals Following Anterior Cruciate Ligament Reconstruction.Brain sciences · 2026Article
- Central Neuromuscular Reactivation Using Digital Mindfulness and Motor Imagery Intervention for Chronic Knee Pain in Patients With Obesity: Prospective, Single-Center Study.JMIR formative research · 2026Article
- Relationship Between Quadriceps Neuromuscular Activity and Knee Extensor Strength at Four Months After ACL Reconstruction in High-Level Young Athletes.Orthopaedic journal of sports medicine · 2025Article
- Evidence for arthrogenic inhibition of the gluteus medius after anterior cruciate ligament injury: A systematic review.Journal of experimental orthopaedics · 2025Article
- Why Should Return to Sport Be Delayed by up to Two Years After ACL Reconstruction? A Narrative Review of the Biological, Surgical and Rehabilitation Evidence.Journal of clinical medicine · 2025Review
- Influence of Graft Type on Muscle Contractile Dynamics After ACL Reconstruction: A 9-Month Tensiomyographic Follow-Up.Diagnostics (Basel, Switzerland) · 2025Article
- Retrospective Study on the Efficacy of Platelet-Rich Plasma Treatment in the Recovery of Quadriceps Muscle Strength After Anterior Cruciate Ligament Reconstruction in Non-Professional Athletes.Journal of clinical medicine · 2025Article
- Rethinking the Assessment of Arthrogenic Muscle Inhibition After ACL Reconstruction: Implications for Return-to-Sport Decision-Making-A Narrative Review.Journal of clinical medicine · 2025Review
- Using the Single-Leg Hop Test to Determine Knee Extension Strength After Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2025Article
- Nutritional Interventions to Attenuate Quadriceps Muscle Deficits following Anterior Cruciate Ligament Injury and Reconstruction.Sports medicine (Auckland, N.Z.) · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Introduction: It is well documented that marked weakness of the quadriceps is present after knee joint injury. This joint trauma induces a presynaptic reflex inhibition of musculature surrounding the joint, termed arthrogenic muscle inhibition (AMI). The extent to which anterior cruciate ligament (ACL) injury affects thigh musculature motor unit activity, which may affect restoration of thigh muscle strength after injury, is undetermined. Methods: A randomized protocol of knee flexion and extension isometric contractions (10%-50% maximal voluntary isometric contraction) were performed for each leg on 54 subjects with electromyography array electrodes placed on the vastus medialis, vastus lateralis, semitendinosus, and biceps femoris. Longitudinal assessments for motor unit recruitment and average firing rate were acquired at 6-month intervals for 1 year post ACL injury. Results: The ACL-injured population demonstrated smaller quadriceps and hamstrings motor unit size (assessed Discussion: Motor unit activity was altered after ACLR up to 12 months post-surgery. Further research is warranted to optimize rehabilitation interventions that adequately address altered motor unit activity and improve safety and success with return to sport after ACLR. In the interim, evidence based clinical reasoning with a focus on development of muscular strength and power capacity should be the impetus behind rehabilitation programming to address motor control deficits.
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Registered trials
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