Evidence map›Paper›PMID 37025387›Full record

ReviewJournal of oral microbiology2023

Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis.

Ali A Abdulkareem, Firas B Al-Taweel, Ali J B Al-Sharqi, Sarhang S Gul, Aram Sha, Iain L C Chapple

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of oral microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05999175 (Evaluation of the Tolerability, Safety of Use, and Efficacy of Cosmetic Products for the Oral Care. In Use Test Under Dentist Control), which is not on this map. Cited by 217 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 10 pooled it
64.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05999175 nacompletednot on this map

Evaluation of the Tolerability, Safety of Use, and Efficacy of Cosmetic Products for the Oral Care. In Use Test Under Dentist Control

TypeinterventionalSponsorBiokosmes SrlRan2022 to 2022Enrolled84ConditionsOral Hygiene, Toothbrushing, Dental PlaqueArmsthe toothpaste is used with a standard toothbrush without any claims 3 times a day after the main meals for 28 days., the mint toothpaste and mouthwash are used with the scalar toothbrush 33 medium with antibacterial " Spazzolino tau-marin®" 3 times a day after the main meals for 28 days., subjects of this group will use their routine oral hygiene products.
3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 10 syntheses or guidelines pooled it, 295 citations in OpenAlex.

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  15. Plaque Removal and Gingival Bleeding Using Biodegradable Toothbrushes: Salvadora persica, Bamboo, and Nylon: A Comparative Study.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Trial
  16. Article
  17. Epithelial Inflammatory iNOS-Nitrate Axis EnhancesInternational journal of molecular sciences · 2026
    Article
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  19. Review
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157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ali A AbdulkareemDepartment of Periodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq.ORCID https://orcid.org/0000-0003-0102-6715
Firas B Al-TaweelDepartment of Periodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq.
Ali J B Al-SharqiDepartment of Periodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq.
Sarhang S GulCollege of Dentistry, University of Sulaimani, Sulaimani, Iraq.
Aram ShaCollege of Dentistry, University of Sulaimani, Sulaimani, Iraq.
Iain L C ChapplePeriodontal Research Group, Institute of Clinical Sciences, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK.
University of Baghdad · IQUniversity of Sulaimani · IQUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primary etiological agent for the initiation and progression of periodontal disease is the dental plaque biofilm which is an organized aggregation of microorganisms residing within a complex intercellular matrix. The non-specific plaque hypothesis was the first attempt to explain the role of the dental biofilm in the pathogenesis of periodontal diseases. However, the introduction of sophisticated diagnostic and laboratory assays has led to the realisation that the development of periodontitis requires more than a mere increase in the biomass of dental plaque. Indeed, multispecies biofilms exhibit complex interactions between the bacteria and the host. In addition, not all resident microorganisms within the biofilm are pathogenic, since beneficial bacteria exist that serve to maintain a symbiotic relationship between the plaque microbiome and the host's immune-inflammatory response, preventing the emergence of pathogenic microorganisms and the development of dysbiosis. This review aims to highlight the development and structure of the dental plaque biofilm and to explore current literature on the transition from a healthy (symbiotic) to a diseased (dysbiotic) biofilm in periodontitis and the associated immune-inflammatory responses that drive periodontal tissue destruction and form mechanistic pathways that impact other systemic non-communicable diseases.

Indexed as

Dental biofilmdysbiosisinflammationperiodontal diseasesymbiosis

Identifiers

PMID37025387
PMCPMC10071981
OpenAlexW4362585778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.