ArticleFrontiers in surgery2023
The learning curve of endoscopic endonasal transsphenoidal surgery for pituitary adenomas with different surgical complexity.
Article in Frontiers in surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 6 citations in OpenAlex.
- Endocrine and surgical outcomes after medial cavernous sinus wall resection for functioning pituitary adenomas: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Improved visual outcomes after endoscopic endonasal transsphenoidal surgery for pituitary macroadenomas: a single-arm meta-analysis.Acta neurochirurgica · 2026Pooled it
- The learning curve for endoscopic endonasal pituitary surgery: a systematic review.Neurosurgical review · 2023Pooled it
- Frontiers of Innovation and Clinical Application in Endoscopic Endonasal Transsphenoidal Surgery.Journal of clinical medicine · 2026Review
- Learning Curve in Endoscopic Pituitary Surgery: Is Progress over Time Always Guaranteed? A Consecutive Series of 123 Cases from a Single Center.Journal of clinical medicine · 2026Article
- Comparison of complete resection rate and endocrine function improvement between neuronavigation-assisted neuroendoscopic transnasal transsphenoidal approach and microscopic transcranial approach for giant pituitary adenoma.American journal of cancer research · 2026Article
- The utilization of preoperative DWI for pituitary macroadenoma surgical planning: Implications for neuroendoscopic surgery.Endocrine · 2025Article
- Single Center Neurosurgical Outcomes and Trends in Endoscopic Endonasal Resection of 297 Sellar/Suprasellar Tumors Stratified by Duration of Neurosurgical Career.World neurosurgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the learning curve under different surgical complexity in endoscopic transsphenoidal approach for pituitary adenoma. Methods: 273 patients undergoing endoscopic transsphenoidal surgery for pituitary adenoma were collected retrospectively and divided into three groups chronologically (early, middle, and late periods). Surgical complexity was differentiated based on Knosp classification (Knsop grade 0-2 vs. Knosp grade 3-4), tumor maximum diameter (MD) (macroadenomas vs. giant adenomas), and history of previous surgery for pituitary adenoma (first operation vs. reoperation). Then the temporal trends in operative time, surgical outcomes, and postoperative complications were evaluated from early to late. Results: The median operative time decrease from 169 to 147 min across the three periods ( Conclusion: This study showed that complex operations might have a prolonged learning curve. Differentiating surgical difficulty and using multivariate combined analysis may be more helpful in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.