ReviewFrontiers in neurology2023
A review of stress-induced hyperglycaemia in the context of acute ischaemic stroke: Definition, underlying mechanisms, and the status of insulin therapy.
Review in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Fasting blood glucose-to-glycated hemoglobin ratio and functional outcomes in patients with ischemic stroke following endovascular treatment-a meta-analysis.Frontiers in neurology · 2025Pooled it
- Hypoxia-inducible factor-1: A new neuroprotective agent for the treatment of hyperglycemia after stroke.Neural regeneration research · 2026Article
- Improving physiological monitoring and reporting standards in preclinical stroke research.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Development and validation of a nomogram to predict early neurological deterioration in patients with acute ischemic stroke and type 2 diabetes mellitus: the pivotal role of glycemic variability and thrombo-inflammation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Futile recanalization after mechanical thrombectomy in patients with acute ischemic stroke and large ischemic core.Journal of cerebrovascular and endovascular neurosurgery · 2026Article
- Effect of glucose on functional outcome and case-fatality in patients with spontaneous intracerebral hemorrhage.BMC neurology · 2026Article
- Systemic Inflammation Mediates the Association Between Admission Hyperglycemia and Pulmonary Infection or Prognosis in Acute Ischemic Stroke.Mediators of inflammation · 2026Article
- Aqueous Extract of Opuntia ficus-indica (L. Mill) Cladodes Demonstrates Antidiabetic Effect in Normoglycemic and STZ-Induced Diabetic Rats.BioMed research international · 2026Article
- Systemic immune-inflammation index, stress hyperglycemia ratio and triglyceride-glucose index in acute ischemic stroke: an integrated inflammation-stress-metabolism perspective.Frontiers in neurology · 2026Review
- Subtype-associated gut microbial taxa and their clinical correlates in acute ischemic stroke: comparison of large-artery atherosclerosis and small-vessel occlusion.Frontiers in microbiology · 2026Article
- Diagnostic performance of circulating microRNAs for the early diagnosis of different types of acute cerebrovascular disease.PloS one · 2026Article
- Central neuroendocrine dysregulation in ischaemic stroke sequelae: pathophysiological mechanisms-a narrative review.Frontiers in human neuroscience · 2026Review
- Postoperative Blood Glucose Trajectories are Associated with Inflammatory Markers and Functional Outcomes in Acute Ischemic Stroke Treated by Thrombectomy.Vascular health and risk management · 2026Article
- HbA1c Variability as a Predictor of Neurocognitive Decline in Children With Type 1 Diabetes.Cureus · 2025Article
- Differential prognostic value of glycemic dysregulation markers in critically ill individuals with ischemic stroke, with and without diabetes.Diabetology & metabolic syndrome · 2025Article
- The Association Between Stress Hyperglycemia Ratio and Short-Term Outcomes After Successful Recanalization by Mechanical Thrombectomy in Acute Ischemic Stroke Patients.Brain and behavior · 2025Article
- Cardiovascular Risk Factors Involved in Hemorrhagic Transformation After Intravenous Thrombolytic Therapy in Patients with Acute Ischemic Stroke.International journal of molecular sciences · 2025Review
- Triglyceride Glucose Index and Stress Hyperglycemia are Important Factors for Predicting Early Neurological Deterioration in Isolated Acute Pontine Infarction.Brain and behavior · 2025Article
- Impact of intensive insulin therapy on dynamic cardiac function in critically ill patients with stress-induced hyperglycemia.World journal of diabetes · 2025Article
- Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transient elevation of blood glucose produced following acute ischaemic stroke (AIS) has been described as stress-induced hyperglycaemia (SIH). SIH is common even in patients with AIS who have no previous diagnosis of diabetes mellitus. Elevated blood glucose levels during admission and hospitalization are strongly associated with enlarged infarct size and adverse prognosis in AIS patients. However, insulin-intensive glucose control therapy defined by admission blood glucose for SIH has not achieved the desired results, and new treatment ideas are urgently required. First, we explore the various definitions of SIH in the context of AIS and their predictive value in adverse outcomes. Then, we briefly discuss the mechanisms by which SIH arises, describing the dual effects of elevated glucose levels on the central nervous system. Finally, although preclinical studies support lowering blood glucose levels using insulin, the clinical outcomes of intensive glucose control are not promising. We discuss the reasons for this phenomenon.
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