Evidence map›Paper›PMID 37024953›Full record

ArticleBiomaterials research2023

Bacteria-based multiplex system eradicates recurrent infections with drug-resistant bacteria via photothermal killing and protective immunity elicitation.

Youcui Xu, Yi Wu, Yi Hu, Mengran Xu, Yanyan Liu, Yuting Ding, Jing Chen, Xiaowan Huang, Longping Wen, Jiabin Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Youcui Xu *Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, Guangdong, China.
Yi Wu *Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Yi Hu *Center for Biomedical Imaging, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Mengran XuDepartment of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Yanyan LiuDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Yuting DingDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Jing ChenSchool of Life Sciences, Hefei Normal University, Hefei, 230601, Anhui, China.
Xiaowan HuangMedical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, Guangdong, China.
Longping WenMedical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, Guangdong, China. lpwen@ustc.edu.cn.
Jiabin LiDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China. lijiabin@ahmu.edu.cn.
Chen ZhuDepartment of Orthopaedics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, Anhui, China. zhuchena@ustc.edu.cn.ORCID http://orcid.org/0000-0002-6432-7745
University of Science and Technology of China · CNAnhui Medical University · CNGuangdong Academy of Medical Sciences · CNHefei Normal University · CN

Funding

the Anhui Province Natural Science Foundation 1908085MH263the Anhui Provincial Postdoctoral Science Foundation 2019 B302the Key Research and Development Program of Anhui Province 202004j07020013the National Natural Science Foundation of China 32171375the National Natural Science Foundation of China 81871788the Outstanding Youth Fund of Natural Science Foundation of Anhui Province 2108085J41the Scientific Research Fund of Anhui Education Office 2020jyxm2316
6 · The paper itself

Abstract

backgroundThe high mortality associated with drug-resistant bacterial infections is an intractable clinical problem resulting from the low susceptibility of these bacteria to antibiotics and the high incidence of recurrent infections.

methodsHerein, a photosynthetic bacteria-based multiplex system (Rp@Al) composed of natural Rhodopseudomonas palustris (Rp) and Food and Drug Administration-approved aluminum (Al) adjuvant, was developed to combat drug-resistant bacterial infections and prevent their recurrence. We examined its photothermal performance and in vitro and in vivo antibacterial ability; revealed its protective immunomodulatory effect; verified its preventative effect on recurrent infections; and demonstrated the system's safety.

resultsRp@Al exhibits excellent photothermal properties with an effective elimination of methicillin-resistant Staphylococcus aureus (MRSA). In addition, Rp@Al enhances dendritic cell activation and further triggers a T helper 1 (T

conclusionsThis innovative multiplex system, with superior photothermal and immunomodulatory effects, presents great potential for the treatment and prevention of drug-resistant bacterial infections.

Indexed as

Aluminum adjuvantPhotosynthetic bacteriaPhotothermal therapyProtective antimicrobial immunityRecurrent drug-resistant bacterial infectionsRp@Al

Identifiers

PMID37024953
PMCPMC10080897
OpenAlexW4362667466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.