Evidence map›Paper›PMID 37024831›Full record

Observational studyBMC infectious diseases2023

Screening for maternal cytomegalovirus infection during pregnancy and pregnancy outcome in patients with liver disease: an observational study.

Rasha Eletreby, Rasha Abdelaziz, Hend Ibrahim Shousha, Zeinab Hammam, Ayman Hany, Dina Sabry, Basma Elawady, Naglaa Zayed, Ayman Yosry, Shereen Abdel Alem

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rasha EletrebyEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Rasha AbdelazizEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hend Ibrahim ShoushaEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Zeinab HammamEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ayman HanyGynecology and Obstetrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Dina SabryMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Basma ElawadyMedical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Naglaa ZayedEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ayman YosryEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Shereen Abdel AlemEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. shereen.kabeel@kasralainy.edu.eg.ORCID http://orcid.org/0000-0002-3612-0130
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV) infection among pregnant females could induce CMV hepatitis with possible changes in liver stiffness measurement (LSM) which could be reversibly increased during normal pregnancies, particularly in the third trimester. This study aimed to detect the prevalence of CMV infection among pregnant females with and without chronic liver disease and to evaluate the effects of CMV infection on LSM and pregnancy outcomes in comparison to non-CMV-infected pregnant females.

methodsThis is an observational prospective study that included 201 pregnant ladies presented to the liver disease with pregnancy clinic, Cairo University from March 2018 to April 2019. We assessed the laboratory results, abdominal ultrasonography, LSM using ARFI elastography, and pregnancy outcomes.

resultsTwo hundred and one pregnant ladies were divided into ; group 1: pregnant ladies with normal pregnancy (n = 128), group 2: pregnant ladies with chronic liver diseases not related to pregnancy (n = 35), and group 3: pregnant ladies with pregnancy-related liver diseases (n = 38). Positive CMV serology (either/or, +ve CMV-IgM, IgG) was detected in 106/201 patients (52.74%), and fifteen of them had an active infection (IgG +, IgM+, PCR+). Pregnant females with chronic liver diseases not related to pregnancy had significantly higher serum levels of CMV IgM, IgG, and PCR. Moreover, LSM had a significant correlation with CMV IgG and CM_PCR in normal pregnant ladies. Maternal mortality occurred only in pregnant females with chronic liver diseases in 5.7% (2/35).

conclusionMaternal CMV infection carries a significant risk to pregnant females with chronic liver disease. Routine CMV screening for women planning to be pregnant, especially those with chronic liver disease could help to avoid bad maternal and fetal outcomes.

Indexed as

Cytomegalovirus InfectionsDigestive System DiseasesLiver DiseasesPregnancy Complications, InfectiousAntibodies, ViralCytomegalovirusFemaleHumansImmunoglobulin GImmunoglobulin MPregnancyPregnancy OutcomeProspective StudiesAntibodies, ViralImmunoglobulin GImmunoglobulin MCytomegalovirusLiver diseaseOutcomePregnancyScreening

Identifiers

PMID37024831
PMCPMC10080798
OpenAlexW4362666163

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.