Evidence map›Paper›PMID 37024740›Full record

ArticleDigestive diseases and sciences2023

Efficacy of Endoscopic Resection for Rectal Neuroendocrine Tumors Smaller than 15 mm.

Yasuhiko Hamada, Kyosuke Tanaka, Katsumi Mukai, Youichirou Baba, Makoto Kobayashi, Shintaro Tominaga, Hiroyuki Kawabata, Shoma Sawai, Masabumi Kaneko, Shinya Sugimoto and 4 more

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Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Yasuhiko Hamada *Department of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Kyosuke Tanaka *Department of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. kyosuket@med.mie-u.ac.jp.ORCID 0000-0002-1402-7832
Katsumi MukaiDepartment of Gastroenterology, Suzuka General Hospital, Suzuka, Japan.
Youichirou BabaDepartment of Pathology, Suzuka General Hospital, Suzuka, Japan.
Makoto KobayashiDepartment of Gastroenterology, Municipal Yokkaichi Hospital, Yokkaichi, Japan.
Shintaro TominagaDepartment of Gastroenterology, Municipal Yokkaichi Hospital, Yokkaichi, Japan.
Hiroyuki KawabataDepartment of Gastroenterology, Saiseikai Mastusaka General Hospital, Matsusaka, Japan.
Shoma SawaiDepartment of Gastroenterology, Saiseikai Mastusaka General Hospital, Matsusaka, Japan.
Masabumi KanekoDepartment of Gastroenterology, Matsusaka General Hospital, Matsusaka, Japan.
Shinya SugimotoDepartment of Gastroenterology, Ise Red Cross Hospital, Ise, Japan.
Hidekazu InoueDepartment of Gastroenterology, Mie Prefectural Medical Center, Yokkaichi, Japan.
Maya MimuroDepartment of Oncologic Pathology, Mie University Hospital, Tsu, Japan.
Satoshi TamaruDepartment of Clinical Research Center, Mie University Hospital, Tsu, Japan.
Hayato NakagawaDepartment of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Mie University Hospital · JPMatsunami General Hospital · JPYokkaichi Municipal Hospital · JPIse Red Cross Hospital · JPMie Chuo Medical Center · JPMie University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLocal resection, including endoscopic resection, is recommended for rectal neuroendocrine tumors (NETs) < 15 mm in patients without risk factors for metastasis, though the short- and long-term outcomes are unclear.

aimsThis study investigates the efficacy of endoscopic resection for rectal NETs < 15 mm.

methodsThe short- and long-term outcomes of patients with rectal NETs < 15 mm who underwent endoscopic resection and the outcomes of each endoscopic technique were analyzed. The tumors were stratified as < 10 mm (small-size group, SSG) and 10-14 mm (intermediate-size group, IMG).

resultsOverall, 139 lesions (SSG, n = 118; IMG, n = 21) were analyzed. All tumors were classified as G1 (n = 135) or G2 (n = 4) according to the 2019 World Health Organization grading criteria. The complete resection rate was not different between the groups (P = 0.151). Endoscopic submucosal dissection (ESD) and endoscopic submucosal resection with a ligation device (ESMR-L) achieved complete resection rates > 90% in the SSG. The ESMR-L procedure time (P < 0.001) and hospitalized period (P < 0.001) were significantly shorter than those of ESD. ESD achieved a complete resection rate of 80.0% in the IMG. The tumor size did not affect the overall survival or rate of lymph node/distant metastases.

conclusionsEndoscopic resection is a feasible and effective treatment for patients with rectal NETs < 15 mm without the risk factors of metastasis. ESMR-L and ESD are optimal techniques for resecting tumors smaller than 10 mm and 10-14 mm, respectively.

Indexed as

Endoscopic Mucosal ResectionNeuroendocrine TumorsRectal NeoplasmsHumansIntestinal MucosaLymphatic MetastasisRetrospective StudiesTreatment OutcomeCarcinoid tumorEndoscopic mucosal resectionNeoplasm metastasisNeuroendocrine tumorsRectal neoplasmsTransanal endoscopic surgery

Identifiers

PMID37024740
OpenAlexW4362678264

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.