Evidence map›Paper›PMID 37024732›Full record

ArticleEuropean journal of nutrition2023

Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.

Xiaojie Deng, Na Zhang, Qing Wang, Yayan Huang, Yiling Huang, Yaping Lin, Mengjiao Huang, Fan Zheng, Meitian Xiao, Jing Ye

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Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiaojie DengCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Na ZhangCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Qing WangCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Yayan HuangCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Yiling HuangCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Yaping LinCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Mengjiao HuangCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Fan ZhengCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Meitian XiaoCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
Jing YeCollege of Chemical Engineering, Huaqiao University, Xiamen, 361021, China. yejenny@hqu.edu.cn.ORCID http://orcid.org/0000-0002-7712-6600
Huaqiao University · CN

Funding

Major Special Topic of Science and Technology of Fujian Province 2020NZ012013National Nature Science Foundation of China 22078120National Nature Science Foundation of China 81703390the Foreign Cooperation Project of Fujian Province 2020I0018the Foreign Cooperation Project of Fujian Province 2021I0016
6 · The paper itself

Abstract

purposePu-erh tea can be classified into raw pu-erh tea and ripened pu-erh tea. Theabrownin (TB) is one of the major components of pu-erh tea. The difference of the anti-obesity activity between raw pu-erh tea TB (R-TB) and ripened pu-erh tea TB (F-TB) has not been comprehensively investigated yet. Therefore, this article aimed to systemically study the anti-obesity activity and the underlying mechanism of R-TB and F-TB.

methodHigh-fat diet (HFD)-induced C57BL/6J mice with obesity were gavaged with R-TB or F-TB to assess the effect of R-TB and F-TB on the amelioration of obesity, the expression of lipid metabolism-related genes, and the regulation of gut flora imbalance.

resultsAdministration of both R-TB and F-TB could suppress body weight gain, improve insulin sensitivity and glucose homeostasis, regulate the lipid level and reduce the chronic inflammation in obese mice. The underlying anti-obesity mechanism of R-TB and F-TB might involve the regulation of lipogenesis and lipolysis, amelioration of the gut microbiota disorder and promotion of microbial metabolism. Interestingly, R-TB was more efficient in the regulation of blood glucose, reduction of inflammation and suppression of partial adipogenesis-related genes and protein, while F-TB was more effective in the inhibition of lipolysis-related genes and protein. In addition, F-TB might be more effective in adjusting the dysbacteria caused by HFD back to normal by promoting the proliferation of the beneficial microbiota, such as Lactobacillus and Lachnospiraceae_NK4A136_group.

conclusionTaken together, both R-TB and F-TB had the potential to be developed as beneficial dietary supplements or functional foods for ameliorating obesity and obesity-related metabolic disorders, but their effects and the ability to regulate the intestinal flora varied.

Indexed as

Gastrointestinal MicrobiomeAnimalsCatechinDiet, High-FatInflammationMiceMice, Inbred C57BLObesityTeaCatechinTeatheabrowninGut microbiotaObesityPu-erh teaTheabrownin

Identifiers

PMID37024732
OpenAlexW4362659903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.