ArticleNature human behaviour2023
Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank.
Article in Nature human behaviour, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Identifying Modifiable Factors and Their Joint Effect on Amyotrophic Lateral Sclerosis: A Prospective Cohort Study in the UK Biobank.Brain and behavior · 2026Article
- Article
- Machine learning and natural language processing for the identification of potential mental disorders among school-age children: a prospective birth cohort study.BMC medicine · 2026Article
- Oral health, genetic susceptibility, and risk of dementia: a prospective cohort study of UK Biobank.GeroScience · 2026Article
- Edentulism and risk of all-cause dementia and Alzheimer's disease: A competing risk analysis by cognitive status.Journal of Alzheimer's disease : JAD · 2026Article
- Social determinants of health, behavioral factors, and incident dementia: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- Trends in Dementia Incidence, Prevalence, and Mortality among Older Hong Kong Chinese, 2005-2019: A Population-Based Study.Neuroepidemiology · 2026Article
- Excessive sleep duration increases the risk of dementia among older Chinese adults: evidence from the CLHLS.BMC geriatrics · 2026Article
- Associations of combined hearing loss and depression with cognitive impairment among older adults: a sex difference analysis based on evidence from CHARLS.BMC public health · 2026Article
- The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Development and Validation of the Steatotic Liver Disease Lab Data Index: A Refined Diagnostic Tool.Canadian journal of gastroenterology & hepatology · 2026Article
- Cardiovascular risk and cognitive performance: A population-based cross-sectional study (NEDICES2-RISK).PloS one · 2026Article
- Bias-reduced Regression Analysis in Nutrition (BRAiN) index: self-reported diet and predicted cognitive function.Frontiers in nutrition · 2026Article
- Independent and combined associations of diabetes and thyroid disorders with risks of incident dementia.Frontiers in endocrinology · 2026Article
- Modifiable influencing factors and their joint effects on early- and late-onset coronary heart disease.Nature communications · 2025Article
- Maintaining cognitive and physical health across the adult lifespan: the contribution of psychosocial factors.Journal of behavioral medicine · 2025Article
- The role of cardiovascular disease as a mediator in mitigating the impact of ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2025Article
- Network analysis of neuropsychiatric symptoms in mild behavioral impairment among nursing homes: an observational study.BMC geriatrics · 2025Observational
- Machine learning-assisted optimization of dietary intervention against dementia risk.Nature human behaviour · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Previous hypothesis-driven research has identified many risk factors linked to dementia. However, the multiplicity and co-occurrence of risk factors have been underestimated. Here we analysed data of 344,324 participants from the UK Biobank with 15 yr of follow-up data for 210 modifiable risk factors. We first conducted an exposure-wide association study and then combined factors associated with dementia to generate composite scores for different domains. We then evaluated their joint associations with dementia in a multivariate Cox model. We estimated the potential impact of eliminating the unfavourable profiles of risk domains on dementia using population attributable fraction. The associations varied by domain, with lifestyle (16.6%), medical history (14.0%) and socioeconomic status (13.5%) contributing to the majority of dementia cases. Overall, we estimated that up to 47.0%-72.6% of dementia cases could be prevented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.