ArticleScientific reports2023
Association of ovine gammaherpesvirus 2 with an outbreak of acute respiratory disease in dairy cattle.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Seroprevalence of malignant catarrhal fever in cattle and sheep from South Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Outbreak of Respiratory Disease Due to Bovine Respiratory Syncytial Virus with Concomitant Infections byAnimals : an open access journal from MDPI · 2025Article
- The Association ofPathogens (Basel, Switzerland) · 2025Article
- Ovine gammaherpesvirus-2 associated manifestations with concomitant polioencephalomalacia, bovine alphaherpesvirus 1-related pneumonia, and caseous lymphadenitis in a sheep.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Model Systems of Gammaherpesvirus Infection, Immunity, and Disease.Journal of medical virology · 2025Review
- Serological Detection of Ovine Gammaherpesvirus 2 Antibodies in Dairy Farms from Southern Brazil.Microorganisms · 2024Article
- The effects of simultaneous respiratory infections on the nasal shedding of Mycoplasmopsis bovirhinis in dairy calves.Veterinary research communications · 2024Article
- Subclinical Ovine Gammaherpesvirus 2-Related Infections in Free-Ranging Wild Boars (Pathogens (Basel, Switzerland) · 2024Article
- Quantification of ovine gammaherpesvirus 2 in clinical cases of cattle with sheep-associated malignant catarrhal fever.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Characterization of ovine gammaherpesvirus 2 in a goat by nanoplate digital PCR and other diagnostic methods.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- The Role ofPathogens (Basel, Switzerland) · 2024Article
- Immunohistochemical identification of a malignant catarrhal fever virus in cattle with renal diseases from Paraná state, Southern Brazil: a retrospective epidemiological study.Tropical animal health and production · 2023Article
- Possible Association of Bovine Gammaherpesvirus 6 with Pulmonary Disease in a Cow.Animals : an open access journal from MDPI · 2023Article
- Molecular and phylogenetic analysis of herpesviruses in endangered free-ranging cervids of Chile: ovine gammaherpesvirus-2-A novel threat to wild and domestic animal health in Chilean Patagonia.Frontiers in veterinary science · 2023Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the cause of an outbreak of an acute respiratory disease syndrome followed by episodes of diarrhea in a dairy cattle herd from Southern Brazil. Deep nasal swabs (DNS) from asymptomatic calves, calves with pulmonary discomfort, and diarrheic calves after episodes of respiratory distress were used in molecular assays designed to detect the principal pathogens associated with bovine respiratory disease (BRD). Fecal samples were used for the molecular detection of bovine enteric disease agents. Pulmonary tissues from three calves and a cow that died were evaluated by molecular assays to identify 11 agents associated with the development of BRD. The intestinal and pulmonary fragments of one calf and the cow revealed atrophic enteritis and interstitial pneumonia by histopathology, respectively. Immunohistochemistry (IHC) identified intralesional antigens of a malignant catarrhal fever virus, genus Macavirus, within epithelial cells of the lungs and intestines. Molecular assays amplified ovine gammaherpesvirus 2 (OvGHV2) from most of the DNS, and the pulmonary and intestinal fragments from the animals that died, confirming that the Macavirus identified by IHC was OvGHV2. Concomitant pulmonary infections of OvGHV2 with bovine gammaherpesvirus 6 and bovine coronavirus were identified. Additionally, bovine viral diarrhea virus 1b and Aichivirus B were detected in the fecal samples. These findings demonstrated that OvGHV2, a Macavirus, was the disease agent most frequently (81.2%; 13/16) associated with singular pulmonary infections during this outbreak of BRD, suggesting that this virus may be another potential agent of respiratory disease of cattle.
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