ArticleNature communications2023
Distributed processing for value-based choice by prelimbic circuits targeting anterior-posterior dorsal striatal subregions in male mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior.Science advances · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Whole-Brain Mapping of Neuronal Activity Associated with Vocal Socialization Behaviors in Adult Mice.eNeuro · 2026Article
- Dorsal prefrontal cortex drives perseverative behavior in mice.Nature communications · 2026Article
- Comprehensive 3D mapping reveals distinct spatial gradients of SST, PV, and TH interneurons across the mouse caudoputamen.bioRxiv : the preprint server for biology · 2026Article
- Comprehensive 3D mapping reveals distinct spatial gradients of genetically-identified SST, PV, and TH interneurons across the mouse caudoputamen.Frontiers in cellular neuroscience · 2026Article
- Medial prefrontal cortex activity precedes dorsomedial striatum in need for change during history-based flexible behavior.iScience · 2025Article
- Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway.Science advances · 2025Article
- Article
- Temporally and Functionally Distinct Contributions to Value Based Choice Along the Anterior-Posterior Dorsomedial Striatal Axis.bioRxiv : the preprint server for biology · 2025Article
- Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty.eLife · 2025Article
- Striatal arbitration between choice strategies guides few-shot adaptation.Nature communications · 2025Article
- Article
- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
- The Role of the Rat Prefrontal Cortex and Sex Differences in Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A normative framework dissociates need and motivation in hypothalamic neurons.Science advances · 2024Article
- Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations.Nature communications · 2024Article
- A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A feature-specific prediction error model explains dopaminergic heterogeneity.Nature neuroscience · 2024Article
- Stochastic characterization of navigation strategies in an automated variant of the Barnes maze.eLife · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Fronto-striatal circuits have been implicated in cognitive control of behavioral output for social and appetitive rewards. The functional diversity of prefrontal cortical populations is strongly dependent on their synaptic targets, with control of motor output mediated by connectivity to dorsal striatum. Despite evidence for functional diversity along the anterior-posterior striatal axis, it is unclear how distinct fronto-striatal sub-circuits support value-based choice. Here we found segregated prefrontal populations defined by anterior/posterior dorsomedial striatal target. During a feedback-based 2-alternative choice task, single-photon imaging revealed circuit-specific representations of task-relevant information with prelimbic neurons targeting anterior DMS (PL::A-DMS) robustly modulated during choices and negative outcomes, while prelimbic neurons targeting posterior DMS (PL::P-DMS) encoded internal representations of value and positive outcomes contingent on prior choice. Consistent with this distributed coding, optogenetic inhibition of PL::A-DMS circuits strongly impacted choice monitoring and responses to negative outcomes while inhibition of PL::P-DMS impaired task engagement and strategies following positive outcomes. Together our data uncover PL populations engaged in distributed processing for value-based choice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.