ArticleNature communications2023
TREM2
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In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- The CCR2 inflammatory pathway is a target for improving severe disease and pulmonary inflammation in experimental COVID-19.Virulence · 2026Article
- Identification of a spatially organized TREM2-associated permissive macrophage niche in human pulmonary tuberculosis alveolar pneumonia.Nature communications · 2026Article
- Cross-species integration of single-cell data reveals conserved pathology-associated cell populations across animal models and human samples.Cell reports methods · 2026Article
- Combating respiratory diseases with mucosal vaccines.Journal of virology · 2026Review
- TREM2-driven peripheral macrophage regulation in inflammatory diseases: implications extending beyond neurological disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques.Research square · 2025Article
- Review
- Monitoring Macrophage Polarization in Infectious Disease, Lesson From SARS-CoV-2 Infection.Reviews in medical virology · 2025Review
- TREM2Frontiers in immunology · 2025Review
- Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.PLoS pathogens · 2025Article
- Coupling of Alzheimer's Disease Genetic Risk Factors with Viral Susceptibility and Inflammation.Aging and disease · 2024Review
- Unmasking the hidden impact of viruses on tuberculosis risk.Trends in immunology · 2024Review
- Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.bioRxiv : the preprint server for biology · 2024Article
- Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models.Zoological research · 2024Review
- Harnessing the power of IFN for therapeutic approaches to COVID-19.Journal of virology · 2024Review
- Dynamics of host immune responses and a potential function of Trem2Respiratory research · 2024Article
- Function and mechanism of TREM2 in bacterial infection.PLoS pathogens · 2024Review
- Bioinformatics and system biology analysis revealed the crosstalk between COVID-19 and osteoarthritis.Immunity, inflammation and disease · 2023Article
- Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis.Trends in immunology · 2023Review
- Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology.Nature communications · 2023Article
Corrections and comments
- Update of
Authors and funding
28 authors at 2 institutions in 1 country.
Amit A Upadhyay *Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-0952-4164
Elise G Viox *Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Timothy N Hoang *Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-7781-1130
Arun K BoddapatiEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Maria PinoDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Michelle Y-H LeeDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-5722-1109
Jacqueline CorryDepartment of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1942-1529
Zachary StronginDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
David A CowanEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Elizabeth N BeagleEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Tristan R HortonEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Sydney HamiltonEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Hadj AouedEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Justin L HarperDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6948-3501
Christopher T EdwardsDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6552-4097
Kevin NguyenDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Kathryn L PellegriniEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Gregory K TharpEmory NPRC Genomics Core Laboratory, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0003-3075-755X
Anne PiantadosiDepartment of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-5942-1534
Rebecca D LevitDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0001-5405-8716
Rama R AmaraDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6309-6797
Simon M Barratt-BoyesDepartment of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.
Susan P RibeiroDepartment of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, USA.
Rafick P SekalyDepartment of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-7816-4828
Thomas H VanderfordDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Raymond F SchinaziDepartment of Pediatrics, School of Medicine, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, USA.ORCID 0000-0002-6688-3614
Mirko PaiardiniDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA. mirko.paiardini@emory.edu.ORCID 0000-0002-7276-3600
Steven E BosingerDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA. steven.bosinger@emory.edu.ORCID 0000-0002-2116-5061
Emory University · USUniversity of Pittsburgh · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MVery early drivers of neutrophilic inflammation in cardiac ischemia-reperfusionR01HL140223 · NHLBI · EMORY UNIVERSITY · PI Rebecca Diane Levit · 2018 to 2026
$4.4MTowards Suppression and Elimination of HIV in the CNSR01MH116695 · NIMH · EMORY UNIVERSITY · PI SCHINAZI, RAYMOND FELIX, TYOR, WILLIAM R · 2018 to 2022
$3.4MIllumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985kNHLBI NIH HHS R01 HL140223NIH HHS P51 OD011132NIH HHS S10 OD026799NIMH NIH HHS R01 MH116695
Abstract
The immunopathological mechanisms driving the development of severe COVID-19 remain poorly defined. Here, we utilize a rhesus macaque model of acute SARS-CoV-2 infection to delineate perturbations in the innate immune system. SARS-CoV-2 initiates a rapid infiltration of plasmacytoid dendritic cells into the lower airway, commensurate with IFNA production, natural killer cell activation, and a significant increase of blood CD14
Indexed as
COVID-19AnimalsCytokinesHumansInflammationMacaca mulattaMacrophagesMembrane GlycoproteinsReceptors, ImmunologicSARS-CoV-2CytokinesMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, human
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.