Evidence map›Paper›PMID 37024382›Full record

Trial reportAnnals of emergency medicine2023

Clinical and Laboratory Predictors of Dehydration Severity in Children With Diabetic Ketoacidosis.

Jennifer L Trainor, Nicole S Glaser, Leah Tzimenatos, Michael J Stoner, Kathleen M Brown, Julie K McManemy, Jeffrey E Schunk, Kimberly S Quayle, Lise E Nigrovic, Arleta Rewers and 8 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 1 country.

Jennifer L TrainorDivision of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address: jtrainor@luriechildrens.org.
Nicole S GlaserDepartment of Pediatrics, University of California Davis Health, University of California, Davis, School of Medicine, Sacramento, CA.
Leah TzimenatosDepartment of Emergency Medicine, University of California Davis Health, University of California, Davis, School of Medicine, Sacramento, CA.
Michael J StonerDivision of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH.
Kathleen M BrownDivision of Emergency Medicine, Department of Pediatrics, Children's National Medical Center, George Washington School of Medicine and Health Sciences, Washington, DC.
Julie K McManemyDivision of Emergency Medicine; Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Jeffrey E SchunkDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, (UT).
Kimberly S QuayleDivision of Emergency Medicine, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine in St. Louis, St. Louis, MO.
Lise E NigrovicDivision of Emergency Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Arleta RewersDivision of Emergency Medicine, Department of Pediatrics, Colorado Children's Hospital, University of Colorado-Denver School of Medicine, Aurora, CO.
Sage R MyersDivision of Emergency Medicine, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Jonathan E BennettDivision of Emergency Medicine, Nemours/A.I. duPont Hospital for Children, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
Maria Y KwokDivision of Emergency Medicine, Department of Pediatrics, New York Presbyterian Morgan Stanley Children's Hospital, Columbia University College of Physicians and Surgeons, New York, NY.
Cody S OlsenDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, (UT).
T Charles CasperDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, (UT).
Simona GhettiDepartment of Psychology, and the Center for Mind and Brain, University of California Davis, Davis, CA.
Nathan KuppermannDepartment of Pediatrics, University of California Davis Health, University of California, Davis, School of Medicine, Sacramento, CA; Department of Emergency Medicine, University of California Davis Health, University of California, Davis, School of Medicine, Sacramento, CA.
Pediatric Emergency Care Applied Research Network (PECARN) FLUID Study Group
University of California, Davis · USUniversity of Utah · USChildren's Hospital Colorado · USAlfred I. duPont Hospital for Children · USBaylor College of Medicine · USBoston Children's Hospital · USChildren's Hospital of Philadelphia · USChildren's National · USMorgan Stanley Children's Hospital · USNationwide Children's Hospital · USNorthwestern University · USSt. Louis Children's Hospital · US

Funding

Fluid Therapy and Cerebral Injury in Pediatric Diabetic KetoacidosisU01HD062417 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GLASER, NICOLE S, KUPPERMANN, NATHAN · 2012 to 2014
$1.7M
NICHD NIH HHS U01 HD062417
6 · The paper itself

Abstract

STUDY

objectiveOur primary objective was to characterize the degree of dehydration in children with diabetic ketoacidosis (DKA) and identify physical examination and biochemical factors associated with dehydration severity. Secondary objectives included describing relationships between dehydration severity and other clinical outcomes.

methodsIn this cohort study, we analyzed data from 753 children with 811 episodes of DKA in the Pediatric Emergency Care Applied Research Network Fluid Therapies Under Investigation Study, a randomized clinical trial of fluid resuscitation protocols for children with DKA. We used multivariable regression analyses to identify physical examination and biochemical factors associated with dehydration severity, and we described associations between dehydration severity and DKA outcomes.

resultsMean dehydration was 5.7% (SD 3.6%). Mild (0 to <5%), moderate (5 to <10%), and severe (≥10%) dehydration were observed in 47% (N=379), 42% (N=343), and 11% (N=89) of episodes, respectively. In multivariable analyses, more severe dehydration was associated with new onset of diabetes, higher blood urea nitrogen, lower pH, higher anion gap, and diastolic hypertension. However, there was substantial overlap in these variables between dehydration groups. The mean length of hospital stay was longer for patients with moderate and severe dehydration, both in new onset and established diabetes.

conclusionMost children with DKA have mild-to-moderate dehydration. Although biochemical measures were more closely associated with the severity of dehydration than clinical assessments, neither were sufficiently predictive to inform rehydration practice.

Indexed as

Diabetes MellitusDiabetic KetoacidosisHypertensionChildCohort StudiesDehydrationFluid TherapyHumansRetrospective Studies

Identifiers

PMID37024382
PMCPMC10523885
OpenAlexW4362634856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.