Evidence map›Paper›PMID 37024073›Full record

ArticleMicrovascular research2023

Alterations in retinal pulse wave velocity under experimental ocular hypertension.

Mahnaz Shahidi, Amir Nankali, Anthony E Felder, Mansour Rahimi, Sophie Leahy, Nathanael Matei

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microvascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mahnaz ShahidiDepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USA. Electronic address: mshahidi@usc.edu.
Amir NankaliDepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
Anthony E FelderRichard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, USA.
Mansour RahimiDepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
Sophie LeahyDepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
Nathanael MateiDepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USUniversity of Illinois Chicago · US

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Noninvasive Imaging of Chorioretinal Oxygen TensionR01EY017918 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHAHIDI, MAHNAZ · 2007 to 2022
$6.2M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY017918
6 · The paper itself

Abstract

Impairments of blood flow and autoregulation have been implicated in diabetic retinopathy and glaucoma. Thus, identifying biomarkers of retinal vascular compliance and regulatory capacity is of potential value for understanding the pathophysiology and evaluating onset or progression of disease. Pulse wave velocity (PWV) represents the speed of the pulse-propagated pressure wave within blood vessels and has shown promise as a marker of vascular compliance. The purpose of the current study was to report a method for comprehensive assessment of retinal PWV based on spectral analysis of pulsatile intravascular intensity waveforms and determine alterations due to experimental ocular hypertension. Retinal PWV was linearly related to vessel diameter. Increased retinal PWV was associated with elevated intraocular pressure. Retinal PWV has the potential to serve as a vasoregulation biomarker for investigating vascular factors that contribute to the development of retinal diseases in animal models.

Indexed as

GlaucomaHypertensionOcular HypertensionBiomarkersBlood Flow VelocityBlood PressureHumansPulse Wave AnalysisVascular ResistanceBiomarkersImagingOcular hypertensionPulse wave velocityRetina

Identifiers

PMID37024073
PMCPMC10330223
OpenAlexW4362635473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.