ArticleSchizophrenia bulletin2023
Review of Major Social Determinants of Health in Schizophrenia-Spectrum Psychotic Disorders: III. Biology.
Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Defining Urbanicity in the Context of Psychosis Research: A Qualitative Systematic Literature Review.Schizophrenia bulletin · 2025Pooled it
- Social Determinants of Health and Suicide-Related Outcomes: A Review of Meta-Analyses.JAMA psychiatry · 2025Pooled it
- Peripheral magnetic stimulation effects on brain activity in older adults with schizophrenia - a randomized controlled pilot study.Frontiers in psychiatry · 2026Trial
- Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia.Schizophrenia research · 2026Article
- Addressing social determinants of health in individuals with mental disorders in clinical practice: review and recommendations.Translational psychiatry · 2025Review
- Modelling the impact of environmental and social determinants on mental health using generative agents.NPJ digital medicine · 2025Review
- Affective predictors of social support in individuals with schizophrenia.Schizophrenia research · 2025Article
- The association between racism and psychosis: An umbrella review.PLOS mental health · 2025Article
- Exploring the Impact of Schizophrenia and Its Pharmacological Treatment on Health-Related Quality of Life and Treatment Preferences.Patient preference and adherence · 2025Article
- An Evaluation of a Women's Clinic: The Healthcare and Learning Project of the Functional Unit for Women with Schizophrenia.Healthcare (Basel, Switzerland) · 2024Review
- Social connections as determinants of cognitive health and as targets for social interventions in persons with or at risk of Alzheimer's disease and related disorders: a scoping review.International psychogeriatrics · 2024Article
- Factors associated with the psychosis continuum among homeless people: Comparison between natives and migrants in the SAMENTA study.Journal of migration and health · 2024Article
- Retinal Neurodegeneration as a Potential Biomarker of Accelerated Aging in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2023Article
- Monitoring the Effectiveness of Treatment in Women with Schizophrenia: New Specialized Cooperative Approaches.Brain sciences · 2023Review
- Schizophrenia: A Review of Social Risk Factors That Affect Women.Behavioral sciences (Basel, Switzerland) · 2023Review
- Introduction to the Section on Major Social Determinants of Health in Schizophrenia-Spectrum Psychotic Disorders.Schizophrenia bulletin · 2023Article
- Review of Major Social Determinants of Health in Schizophrenia-Spectrum Disorders: II. Assessments.Schizophrenia bulletin · 2023Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundSocial determinants of health (SDoHs) are nonmedical factors that significantly impact health and longevity. We found no published reviews on the biology of SDoHs in schizophrenia-spectrum psychotic disorders (SSPD). STUDY
designWe present an overview of pathophysiological mechanisms and neurobiological processes plausibly involved in the effects of major SDoHs on clinical outcomes in SSPD. STUDY
resultsThis review of the biology of SDoHs focuses on early-life adversities, poverty, social disconnection, discrimination including racism, migration, disadvantaged neighborhoods, and food insecurity. These factors interact with psychological and biological factors to increase the risk and worsen the course and prognosis of schizophrenia. Published studies on the topic are limited by cross-sectional design, variable clinical and biomarker assessments, heterogeneous methods, and a lack of control for confounding variables. Drawing on preclinical and clinical studies, we propose a biological framework to consider the likely pathogenesis. Putative systemic pathophysiological processes include epigenetics, allostatic load, accelerated aging with inflammation (inflammaging), and the microbiome. These processes affect neural structures, brain function, neurochemistry, and neuroplasticity, impacting the development of psychosis, quality of life, cognitive impairment, physical comorbidities, and premature mortality. Our model provides a framework for research that could lead to developing specific strategies for prevention and treatment of the risk factors and biological processes, thereby improving the quality of life and increasing the longevity of people with SSPD.
conclusionsBiology of SDoHs in SSPD is an exciting area of research that points to innovative multidisciplinary team science for improving the course and prognosis of these serious psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.