ArticleProceedings of the National Academy of Sciences of the United States of America2023
African swine fever virus I73R is a critical virulence-related gene: A potential target for attenuation.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
17.0field-weighted citation impact, top 1% of its field
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32 citing papers in PubMed, 49 citations in OpenAlex.
- The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs.Emerging microbes & infections · 2026Article
- Deletion of the D345L gene attenuates ASFV and induces protection against homologous and heterologous challenge by enhancing host innate immunity.Emerging microbes & infections · 2026Article
- Hybrid genotype I and II ASFVEmerging microbes & infections · 2026Article
- African swine fever virus pI73R hijacks host mRNA to suppress interferon beta and reveals a druggable target for antiviral intervention.Emerging microbes & infections · 2026Article
- Live-attenuated African swine fever vaccine HLJ/18-7GD is safe in pregnant sows with no impact on reproductive performance or offspring health at a field farm.Emerging microbes & infections · 2026Article
- Genotype II Live-Attenuated ASFV Vaccine Bearing 24 Genes Deletion in 3 Independent Regions Is Able to Provide Complete Protection Against Homologous Lethal Challenge.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Z-Nucleic Acid-Binding Protein (ZBP)1 (DAI/DLM1) Regulation in Antiviral Cell Death Pathways.Pathogens (Basel, Switzerland) · 2026Review
- Evaluation of An I226R and A137R deletion mutant from a genotype I/II recombinant African swine fever virus strain as a live attenuated vaccine in pigs.Veterinary research · 2026Article
- Host-pathogen interactions in African swine fever: From viral entry to systemic disease progression.Cell insight · 2026Review
- Article
- A phylogenetic contribution to understanding the panzootic spread of African swine fever: from the global to the local scale.Virus evolution · 2026Article
- Structural and Functional Analysis of ASFV pI73R Reveals GNB1 Binding and Host Gene Modulation.International journal of molecular sciences · 2025Article
- Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways.Virulence · 2025Review
- Deletion of the African swine fever virus E120R gene completely attenuates its virulence by enhancing host innate immunity and impairing virus release.Emerging microbes & infections · 2025Article
- Hope and hurdles: unlocking the potential of modified live virus vaccines for African swine fever.Emerging microbes & infections · 2025Review
- Alpha-herpesvirus US1 interacts with cGAS to suppress type I IFN responses and antiviral defense.PLoS pathogens · 2025Article
- ASFV pE146L-induced ER remodeling is essential for viral replication.Journal of virology · 2025Article
- An attenuated African swine fever virus with deletions of theJournal of virology · 2025Article
- Review
- Advances in African swine fever virus molecular biology and host interactions contributing to new tools for control.Journal of virology · 2025Review
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Authors and funding
21 authors at 3 institutions in 1 country.
Yingnan LiuKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.ORCID 0000-0001-7335-4422
Zhou ShenState Key Laboratory of Agricultural Microbiology, Key Laboratory of Prevention & Control for African Swine Fever and Other Major Pig Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Zhenhua XieKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Yingying SongKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Yao LiKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Rui LiangState Key Laboratory of Agricultural Microbiology, Key Laboratory of Prevention & Control for African Swine Fever and Other Major Pig Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Lang GongCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.ORCID 0000-0003-0745-0031
Dongdong DiThe Spirit Jinyu Biological Pharmaceutical Co. Ltd., Hohhot, Inner, Mongolia 010030, China.
Jianqi LiuThe Spirit Jinyu Biological Pharmaceutical Co. Ltd., Hohhot, Inner, Mongolia 010030, China.ORCID 0009-0001-4188-3685
Jingyi LiuKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Zongyan ChenKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Wanqi YuKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Lu LvKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Qiuping ZhongKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Xinxin LiaoKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Chuanwen TianKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Rongrong WangKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.ORCID 0000-0003-0215-3257
Qingqing SongThe Spirit Jinyu Biological Pharmaceutical Co. Ltd., Hohhot, Inner, Mongolia 010030, China.
Heng WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
Guiqing PengState Key Laboratory of Agricultural Microbiology, Key Laboratory of Prevention & Control for African Swine Fever and Other Major Pig Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID 0000-0001-8813-6663
Hongjun ChenKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, P.R. China, Shanghai Veterinary Research Institute, Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.ORCID 0000-0002-7254-7596
Shanghai Veterinary Research Institute · CNHuazhong Agricultural University · CNSouth China Agricultural University · CN
Funding
National Natural Science Foundation of China (NSFC) 32170161
Abstract
African swine fever virus (ASFV) is a large, double-stranded DNA virus that causes a fatal disease in pigs, posing a threat to the global pig industry. Whereas some ASFV proteins have been found to play important roles in ASFV-host interaction, the functional roles of many proteins are still largely unknown. In this study, we identified
Indexed as
African Swine FeverAfrican Swine Fever VirusAnimalsGenes, ViralSwineVirulenceVirulence FactorsVirulence FactorsASFVI73Rimmune suppressionlive-attenuated vaccine candidatesingle-stranded RNA binding
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.