Evidence map›Paper›PMID 37022657›Full record

ReviewCerebellum (London, England)2024

Clinical Heterogeneity of Essential Tremor: Understanding Neural Substrates of Action Tremor Subtypes.

Alexander Fanning, Sheng-Han Kuo

Open access · greenAbstract readReview
In one paragraph

Review in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Oscillatory Coupling Between Thalamus, Cerebellum, and Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Six Myths and Misconceptions about Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexander FanningDepartment of Neurology, Columbia University, New York, NY, 10032, USA.
Sheng-Han KuoDepartment of Neurology, Columbia University, New York, NY, 10032, USA. sk3295@cumc.columbia.edu.
Columbia University · US

Funding

Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential TremorR01NS124854 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHYLLIS L FAUST, Sheng-Han Kuo · 2022 to 2026
$2.9M
Targeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
NINDS NIH HHS R01 NS104423NINDS NIH HHS R01 NS118179NINDS NIH HHS R01 NS124854
6 · The paper itself

Abstract

Essential tremor (ET) is a common movement disorder affecting millions of people. Studies of ET patients and perturbations in animal models have provided a foundation for the neural networks involved in its pathophysiology. However, ET encompasses a wide variability of phenotypic expression, and this may be the consequence of dysfunction in distinct subcircuits in the brain. The cerebello-thalamo-cortical circuit is a common substrate for the multiple subtypes of action tremor. Within the cerebellum, three sets of cerebellar cortex-deep cerebellar nuclei connections are important for tremor. The lateral hemispheres and dentate nuclei may be involved in intention, postural and isometric tremor. The intermediate zone and interposed nuclei could be involved in intention tremor. The vermis and fastigial nuclei could be involved in head and proximal upper extremity tremor. Studying distinct cerebellar circuitry will provide important framework for understanding the clinical heterogeneity of ET.

Indexed as

CerebellumEssential TremorAnimalsHumansNeural PathwaysAction tremorCerebellumEssential tremorIntention tremorKinetic tremorPathophysiologyPostural tremor

Identifiers

PMID37022657
PMCPMC10556200
OpenAlexW4362658266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.